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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Mcgowan, K. M. Coulombe, P. A. |
| Description | Author Affiliation: McGowan KM ( Department of Biological Chemistry and Department of Dermatology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.) |
| Abstract | The type I keratin 17 (K17) shows a peculiar localization in human epithelial appendages including hair follicles, which undergo a growth cycle throughout adult life. Additionally K17 is induced, along with K6 and K16, early after acute injury to human skin. To gain further insights into its potential function(s), we cloned the mouse K17 gene and investigated its expression during skin development. Synthesis of K17 protein first occurs in a subset of epithelial cells within the single-layered, undifferentiated ectoderm of embryonic day 10.5 mouse fetuses. In the ensuing 48 h, K17-expressing cells give rise to placodes, the precursors of ectoderm-derived appendages (hair, glands, and tooth), and to periderm. During early development, there is a spatial correspondence in the distribution of K17 and that of lymphoid-enhancer factor (lef-1), a DNA-bending protein involved in inductive epithelial–mesenchymal interactions. We demonstrate that ectopic lef-1 expression induces K17 protein in the skin of adult transgenic mice. The pattern of K17 gene expression during development has direct implications for the morphogenesis of skin epithelia, and points to the existence of a molecular relationship between development and wound repair. |
| ISSN | 00219525 |
| e-ISSN | 15408140 |
| Journal | The Journal of Cell Biology |
| Issue Number | 2 |
| Volume Number | 143 |
| Language | English |
| Publisher | Rockefeller University Press (United States) |
| Publisher Date | 1998-10-19 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Epidermis Embryology Epithelial Cells Cytology Gene Expression Regulation, Developmental Hair Keratins Genetics Animals Cell Lineage Physiology Cloning, Molecular Conserved Sequence DNA, Complementary DNA-Binding Proteins Chemistry Ultrastructure Lymphoid Enhancer-Binding Factor 1 Mice Mice, Transgenic Microscopy, Immunoelectron Molecular Sequence Data Morphogenesis Sequence Homology, Amino Acid Transcription Factors Wound Healing Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Cell Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Medicine |
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