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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Maria, A. S. Kubiak, J. Z. Maro, B. Dujardin, D. Brunet, S. Guillaud, P. |
| Description | Author Affiliation: Brunet S ( Laboratoire de Biologie Cellulaire du Développement, Université Paris 6, Paris, France.) |
| Abstract | During meiosis, two successive divisions occur without any intermediate S phase to produce haploid gametes. The first meiotic division is unique in that homologous chromosomes are segregated while the cohesion between sister chromatids is maintained, resulting in a reductional division. Moreover, the duration of the first meiotic M phase is usually prolonged when compared with mitotic M phases lasting 8 h in mouse oocytes. We investigated the spindle assembly pathway and its role in the progression of the first meiotic M phase in mouse oocytes. During the first 4 h, a bipolar spindle forms and the chromosomes congress near the equatorial plane of the spindle without stable kinetochore– microtubule end interactions. This late prometaphase spindle is then maintained for 4 h with chromosomes oscillating in the central region of the spindle. The kinetochore–microtubule end interactions are set up at the end of the first meiotic M phase (8 h after entry into M phase). This event allows the final alignment of the chromosomes and exit from metaphase. The continuous presence of the prometaphase spindle is not required for progression of the first meiotic M phase. Finally, the ability of kinetochores to interact with microtubules is acquired at the end of the first meiotic M phase and determines the timing of polar body extrusion. |
| ISSN | 00219525 |
| e-ISSN | 15408140 |
| Journal | The Journal of Cell Biology |
| Issue Number | 1 |
| Volume Number | 146 |
| Language | English |
| Publisher | Rockefeller University Press (United States) |
| Publisher Date | 1999-07-12 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Kinetochores Metabolism Meiosis Oocytes Cytology Spindle Apparatus Animals Chromatin Drug Effects Ultrastructure Chromosomes Kinetics Metaphase Mice Microscopy, Electron Microtubule-Associated Proteins Microtubules Neoplasm Proteins Nocodazole Pharmacology Protein Biosynthesis Puromycin Research Support, Non-U.S. Gov't Cell Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Medicine |
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