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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Tokumoto, Y. M. Tang, D. G. Raff, M. C. |
| Description | Author Affiliation: Tang DG ( MRC Laboratory for Molecular Cell Biology and the Biology Department, University College London, London, WC1E 6BT, United Kingdom. d.tang@ucl.ac.uk) |
| Abstract | Oligodendrocytes myelinate axons in the vertebrate central nervous system (CNS). They develop from precursor cells (OPCs), some of which persist in the adult CNS. Adult OPCs differ in many of their properties from OPCs in the developing CNS. In this study we have purified OPCs from postnatal rat optic nerve and cultured them in serum-free medium containing platelet-derived growth factor (PDGF), the main mitogen for OPCs, but in the absence of thyroid hormone in order to inhibit their differentiation into oligodendrocytes. We find that many of the cells continue to proliferate for more than a year and progressively acquire a number of the characteristics of OPCs isolated from adult optic nerve. These findings suggest that OPCs have an intrinsic maturation program that progressively changes the cell's phenotype over many months. When we culture the postnatal OPCs in the same conditions but with the addition of basic fibroblast growth factor (bFGF), the cells acquire these mature characteristics much more slowly, suggesting that the combination of bFGF and PDGF, previously shown to inhibit OPC differentiation, also inhibits OPC maturation. The challenge now is to determine the molecular basis of such a protracted maturation program and how the program is restrained by bFGF. |
| ISSN | 00219525 |
| e-ISSN | 15408140 |
| Journal | The Journal of Cell Biology |
| Issue Number | 5 |
| Volume Number | 148 |
| Language | English |
| Publisher | Rockefeller University Press (United States) |
| Publisher Date | 2000-03-06 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Cell Differentiation Physiology Oligodendroglia Cytology Metabolism Stem Cells Animals Animals, Newborn Antigens, Differentiation Biosynthesis Cell Count Drug Effects Cell Cycle Cell Death Cell Movement Cell Size Cells, Cultured Culture Media, Serum-Free Pharmacology Fibroblast Growth Factor 2 Optic Nerve Phenotype Platelet-Derived Growth Factor Rats, Sprague-Dawley Research Support, Non-U.S. Gov't Cell Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Medicine |
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