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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Biggins, Sue Buvelot, Stéphanie Tatsutani, Sean Y. Vermaak, Danielle |
| Description | Author Affiliation: Buvelot S ( Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.) |
| Abstract | Ipl1p is the budding yeast member of the Aurora family of protein kinases, critical regulators of genomic stability that are required for chromosome segregation, the spindle checkpoint, and cytokinesis. Using time-lapse microscopy, we found that Ipl1p also has a function in mitotic spindle disassembly that is separable from its previously identified roles. Ipl1–GFP localizes to kinetochores from G1 to metaphase, transfers to the spindle after metaphase, and accumulates at the spindle midzone late in anaphase. Ipl1p kinase activity increases at anaphase, and ipl1 mutants can stabilize fragile spindles. As the spindle disassembles, Ipl1p follows the plus ends of the depolymerizing spindle microtubules. Many Ipl1p substrates colocalize with Ipl1p to the spindle midzone, identifying additional proteins that may regulate spindle disassembly. We propose that Ipl1p regulates both the kinetochore and interpolar microtubule plus ends to regulate its various mitotic functions. |
| ISSN | 00219525 |
| e-ISSN | 15408140 |
| Journal | The Journal of Cell Biology |
| Issue Number | 3 |
| Volume Number | 160 |
| Language | English |
| Publisher | Rockefeller University Press (United States) |
| Publisher Date | 2003-02-03 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Cell Division Physiology Chromosome Segregation Microtubules Metabolism Protein Kinases Saccharomyces Cerevisiae Proteins Saccharomycetales Enzymology Spindle Apparatus Anaphase Aurora Kinases Green Fluorescent Proteins Intracellular Signaling Peptides And Proteins Kinetochores Luminescent Proteins Metaphase Mutation Polymers Genetics Protein-Serine-Threonine Kinases Recombinant Fusion Proteins Cytology Ultrastructure Tubulin Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S. Cell Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Medicine |
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