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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Peters, Jan-michael Zimmer, Christine Hauf, Silke Laterra, Sabrina Rieder, Conly L. Cole, Richard W. Heckel, Armin Schnapp, Gisela Van Meel, Jacques Walter, Rainer |
| Description | Author Affiliation: Hauf S ( Research Institute of Molecular Pathology, Dr. Bohr-Gasse 7, 1030 Vienna, Austria.) |
| Abstract | The proper segregation of sister chromatids in mitosis depends on bipolar attachment of all chromosomes to the mitotic spindle. We have identified the small molecule Hesperadin as an inhibitor of chromosome alignment and segregation. Our data imply that Hesperadin causes this phenotype by inhibiting the function of the mitotic kinase Aurora B. Mammalian cells treated with Hesperadin enter anaphase in the presence of numerous monooriented chromosomes, many of which may have both sister kinetochores attached to one spindle pole (syntelic attachment). Hesperadin also causes cells arrested by taxol or monastrol to enter anaphase within <1 h, whereas cells in nocodazole stay arrested for 3–5 h. Together, our data suggest that Aurora B is required to generate unattached kinetochores on monooriented chromosomes, which in turn could promote bipolar attachment as well as maintain checkpoint signaling. |
| ISSN | 00219525 |
| e-ISSN | 15408140 |
| Journal | The Journal of Cell Biology |
| Issue Number | 2 |
| Volume Number | 161 |
| Language | English |
| Publisher | Rockefeller University Press (United States) |
| Publisher Date | 2003-04-28 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Aneugens Pharmacology Endopeptidases Eukaryotic Cells Enzymology Indoles Kinetochores Microtubules Mitosis Genetics Protein-Serine-Threonine Kinases Metabolism Spindle Apparatus Sulfonamides Anaphase Drug Effects Animals Aurora Kinase B Aurora Kinases Cell Cycle Proteins Chromosome Segregation Cytology Genes, Cdc Physiology HeLa Cells Nocodazole Paclitaxel Phenotype Polyploidy Protein Kinases Pyrimidines RNA, Small Interfering Separase Thiones Research Support, Non-U.S. Gov't Cell Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Medicine |
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