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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Kilmartin, John V. |
| Description | Author Affiliation: Kilmartin JV ( MRC Laboratory of Molecular Biology, Cambridge CB2 2QH, UK. jvk@mrc-lmb.cam.ac.uk) |
| Abstract | Centrins are calmodulin-like proteins present in microtubule-organizing centers. The Saccharomyces cerevisiae centrin, Cdc31p, was functionally tagged with a single Z domain of protein A, and used in pull-down experiments to isolate Cdc31p-binding proteins. One of these, Sfi1p, localizes to the half-bridge of the spindle pole body (SPB), where Cdc31p is also localized. Temperature-sensitive mutants in SFI1 show a defect in SPB duplication and genetic interactions with cdc31-1. Sfi1p contains multiple internal repeats that are also present in a Schizosaccharomyces pombe protein, which also localizes to the SPB, and in several human proteins, one of which localizes close to the centriole region. Cdc31p binds directly to individual Sfi1 repeats in a 1:1 ratio, so a single molecule of Sfi1p binds multiple molecules of Cdc31p. The centrosomal human protein containing Sfi1 repeats also binds centrin in the repeat region, showing that this centrin-binding motif is conserved. |
| ISSN | 00219525 |
| e-ISSN | 15408140 |
| Journal | The Journal of Cell Biology |
| Issue Number | 7 |
| Volume Number | 162 |
| Language | English |
| Publisher | Rockefeller University Press (United States) |
| Publisher Date | 2003-09-29 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Repressor Proteins Genetics Metabolism Saccharomyces Cerevisiae Proteins Schizosaccharomyces Pombe Proteins Spindle Apparatus Amino Acid Sequence Binding Sites Physiology Calcium Calcium-Binding Proteins Cell Cycle Proteins Elasticity Green Fluorescent Proteins Indicators And Reagents Luminescent Proteins Molecular Sequence Data Phenotype Chemistry Saccharomyces Cerevisiae Schizosaccharomyces Sequence Homology, Amino Acid Cell Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Medicine |
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