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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Karle, Kathrin Kröning, Ann-kathrin Sendtner, Michael Andreassi, Catia Jablonka, Sibylle Monani, Umrao R. Rossoll, Wilfried |
| Description | Author Affiliation: Rossoll W ( Institute for Clinical Neurobiology, University of Wuerzburg, 97080 Wuerzburg, Germany.) |
| Abstract | Spinal muscular atrophy (SMA), a common autosomal recessive form of motoneuron disease in infants and young adults, is caused by mutations in the survival motoneuron 1 (SMN1) gene. The corresponding gene product is part of a multiprotein complex involved in the assembly of spliceosomal small nuclear ribonucleoprotein complexes. It is still not understood why reduced levels of the ubiquitously expressed SMN protein specifically cause motoneuron degeneration. Here, we show that motoneurons isolated from an SMA mouse model exhibit normal survival, but reduced axon growth. Overexpression of Smn or its binding partner, heterogeneous nuclear ribonucleoprotein (hnRNP) R, promotes neurite growth in differentiating PC12 cells. Reduced axon growth in Smn-deficient motoneurons correlates with reduced β-actin protein and mRNA staining in distal axons and growth cones. We also show that hnRNP R associates with the 3′ UTR of β-actin mRNA. Together, these data suggest that a complex of Smn with its binding partner hnRNP R interacts with β-actin mRNA and translocates to axons and growth cones of motoneurons. |
| ISSN | 00219525 |
| e-ISSN | 15408140 |
| Journal | The Journal of Cell Biology |
| Issue Number | 4 |
| Volume Number | 163 |
| Language | English |
| Publisher | Rockefeller University Press (United States) |
| Publisher Date | 2003-11-24 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Actins Genetics Growth Cones Metabolism Motor Neurons Nerve Tissue Proteins Deficiency Physiology Spinal Cord Growth & Development 3' Untranslated Regions Animals Axons Cell Differentiation Cell Survival Cyclic AMP Response Element-Binding Protein Disease Models, Animal Ultrastructure Heterogeneous-Nuclear Ribonucleoproteins Mice Mice, Transgenic Cytology PC12 Cells RNA, Messenger RNA-Binding Proteins SMN Complex Proteins Survival Of Motor Neuron 1 Protein Research Support, Non-U.S. Gov't Cell Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Medicine |
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