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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Grabner, Henrik Jacob, Claire Atanasoski, Suzana Suter, Ueli |
| Description | Author Affiliation: Jacob C ( Department of Biology, Institute of Cell Biology, ETH Zurich, CH-8093 Zurich, Switzerland. claire.jacob@cell.biol.ethz.ch) |
| Abstract | Transforming growth factor β (TGFβ) promotes epithelial cell differentiation but induces Schwann cell proliferation. We show that the protooncogene Ski (Sloan-Kettering viral oncogene homologue) is an important regulator of these effects. TGFβ down-regulates Ski in epithelial cells but not in Schwann cells. In Schwann cells but not in epithelial cells, retinoblastoma protein (Rb) is up-regulated by TGFβ. Additionally, both Ski and Rb move to the cytoplasm, where they partially colocalize. In vivo, Ski and phospho-Rb (pRb) appear to interact in the Schwann cell cytoplasm of developing sciatic nerves. Ski overexpression induces Rb hyperphosphorylation, proliferation, and colocalization of both proteins in Schwann cell and epithelial cell cytoplasms independently of TGFβ treatment. Conversely, Ski knockdown in Schwann cells blocks TGFβ-induced proliferation and pRb cytoplasmic relocalization. Our findings reveal a critical function of fine-tuned Ski levels in the control of TGFβ effects on the cell cycle and suggest that at least a part of Ski regulatory effects on TGFβ-induced proliferation of Schwann cells is caused by its concerted action with Rb. |
| ISSN | 00219525 |
| e-ISSN | 15408140 |
| Journal | The Journal of Cell Biology |
| Issue Number | 3 |
| Volume Number | 182 |
| Language | English |
| Publisher | Rockefeller University Press (United States) |
| Publisher Date | 2008-08-11 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Cell Cycle DNA-Binding Proteins Metabolism Epithelial Cells Cytology Proto-Oncogene Proteins Schwann Cells Signal Transduction Transforming Growth Factor Beta Animals Cell Differentiation Cell Line Cell Nucleus Cell Proliferation Down-Regulation Myelin Sheath Organ Specificity Phosphoproteins Phosphorylation Protein Binding Protein Transport Retinoblastoma Protein Sciatic Nerve Embryology Serine Up-Regulation Research Support, Non-U.S. Gov't Cell Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Medicine |
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