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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Goh, Yan Yih Tan, Siew Hwey Michalik, Liliane Philippe, Virginie Tan, Nguan Soon Tan, Chek Kun Tan, Ming Jie Wahli, Walter Chong, Han Chung Ku, Chee Wai |
| Description | Author Affiliation: Chong HC ( School of Biological Sciences, Nanyang Technological University, Singapore 637551.) |
| Abstract | Skin morphogenesis, maintenance, and healing after wounding require complex epithelial–mesenchymal interactions. In this study, we show that for skin homeostasis, interleukin-1 (IL-1) produced by keratinocytes activates peroxisome proliferator–activated receptor β/δ (PPARβ/δ) expression in underlying fibroblasts, which in turn inhibits the mitotic activity of keratinocytes via inhibition of the IL-1 signaling pathway. In fact, PPARβ/δ stimulates production of the secreted IL-1 receptor antagonist, which leads to an autocrine decrease in IL-1 signaling pathways and consequently decreases production of secreted mitogenic factors by the fibroblasts. This fibroblast PPARβ/δ regulation of the IL-1 signaling is required for proper wound healing and can regulate tumor as well as normal human keratinocyte cell proliferation. Together, these findings provide evidence for a novel homeostatic control of keratinocyte proliferation and differentiation mediated via PPARβ/δ regulation in dermal fibroblasts of IL-1 signaling. Given the ubiquitous expression of PPARβ/δ, other epithelial–mesenchymal interactions may also be regulated in a similar manner. |
| ISSN | 00219525 |
| e-ISSN | 15408140 |
| Journal | The Journal of Cell Biology |
| Issue Number | 6 |
| Volume Number | 184 |
| Language | English |
| Publisher | Rockefeller University Press (United States) |
| Publisher Date | 2009-03-23 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Epithelial Cells Metabolism Fibroblasts Interleukin-1 PPAR Delta PPAR-beta Signal Transduction Skin Wound Healing Animals Autocrine Communication Cell Differentiation Cell Proliferation Cells, Cultured Cytokines Enzymology Immunology Gene Knockdown Techniques Homeostasis Intercellular Signaling Peptides And Proteins Interleukin 1 Receptor Antagonist Protein Genetics Interleukin-1alpha Interleukin-1beta MAP Kinase Kinase Kinases Mice Mice, Knockout Organ Culture Techniques Deficiency Paracrine Communication Promoter Regions, Genetic RNA Interference Time Factors Transcription Factor AP-1 Transcriptional Activation Research Support, Non-U.S. Gov't Cell Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Medicine |
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