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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Davis, Anthony J. So, Sairei Chen, David J. |
| Description | Author Affiliation: So S ( Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, 75390, USA.) |
| Abstract | Ataxia telangiectasia mutated (ATM) plays a critical role in the cellular response to DNA damage. In response to DNA double-strand breaks (DSBs), ATM is autophosphorylated at serine 1981. Although this autophosphorylation is widely considered a sign of ATM activation, it is still not clear if autophosphorylation is required for ATM functions including localization to DSBs and activation of ATM kinase activity. In this study, we show that localization of ATM to DSBs is differentially regulated with the initial localization requiring the MRE11–RAD50–NBS1 complex and sustained retention requiring autophosphorylation of ATM at serine 1981. Autophosphorylated ATM interacts with MDC1 and the latter is required for the prolonged association of ATM to DSBs. Ablation of ATM autophosphorylation or knock-down of MDC1 protein affects the ability of ATM to phosphorylate downstream substrates and confer radioresistance. Together, these data suggest that autophosphorylation at serine 1981 stabilizes ATM at the sites of DSBs, and this is required for a proper DNA damage response. |
| ISSN | 00219525 |
| e-ISSN | 15408140 |
| Journal | The Journal of Cell Biology |
| Issue Number | 7 |
| Volume Number | 187 |
| Language | English |
| Publisher | Rockefeller University Press (United States) |
| Publisher Date | 2009-12-28 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Cell Cycle Proteins Physiology DNA Damage DNA-Binding Proteins Protein-Serine-Threonine Kinases Tumor Suppressor Proteins Ataxia Telangiectasia Mutated Proteins Genetics Metabolism DNA Breaks, Double-Stranded DNA Repair Enzymes Mutation Nuclear Proteins Phosphorylation Serine Chemistry Trans-Activators Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S. Cell Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Medicine |
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