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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Akagi, Tsuyoshi Takai, Yoshimi Kawakatsu, Tomomi Sukezane, Taiko Sato, Toshitaka Grigoriev, Ilya Hotta, Azusa Akhmanova, Anna Nakatani, Tomoya Hamaji, Tomoko Matsui, Chiyuki Mimori-kiyosue, Yuko |
| Description | Author Affiliation: Hotta A ( KAN Research Institute, Inc., Chuo-ku, Kobe 650-0047, Japan.) |
| Abstract | LL5β has been identified as a microtubule-anchoring factor that attaches EB1/CLIP-associating protein (CLASP)–bound microtubule plus ends to the cell cortex. In this study, we show that LL5β and its homologue LL5α (LL5s) colocalize with autocrine laminin-5 and its receptors, integrins α3β1 and α6β4, at the basal side of fully polarized epithelial sheets. Depletion of both laminin receptor integrins abolishes the cortical localization of LL5s, whereas LL5 depletion reduces the amount of integrin α3 at the basal cell cortex. Activation of integrin α3 is sufficient to initiate LL5 accumulation at the cell cortex. LL5s form a complex with the cytoplasmic tails of these integrins, but their interaction might be indirect. Analysis of the three-dimensional distribution of microtubule growth by visualizing EB1-GFP in epithelial sheets in combination with RNA interference reveals that LL5s are required to maintain the density of growing microtubules selectively at the basal cortex. These findings reveal that signaling from laminin–integrin associations attaches microtubule plus ends to the epithelial basal cell cortex. |
| ISSN | 00219525 |
| e-ISSN | 15408140 |
| Journal | The Journal of Cell Biology |
| Issue Number | 5 |
| Volume Number | 189 |
| Language | English |
| Publisher | Rockefeller University Press (United States) |
| Publisher Date | 2010-05-31 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Carrier Proteins Metabolism Epithelial Cells Cytology Intracellular Signaling Peptides And Proteins Laminin Microtubules Nerve Tissue Proteins Animals Genetics Cell Adhesion Cell Membrane Cell Polarity Physiology Integrin Alpha3 Integrin Alpha3beta1 Integrin Alpha6 Integrin Alpha6beta4 Mammary Glands, Animal Mice Mice, Inbred C57BL Microtubule-Associated Proteins Chemistry Protein Binding RNA, Small Interfering Receptors, Laminin Research Support, Non-U.S. Gov't Cell Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Medicine |
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