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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Pellman, David Li, Chao-chin Breuer, Manuel Brunet, Stéphane Kolano, Agnieszka Tsai, Ting-fen Kwon, Mijung Verlhac, Marie-hélène |
| Description | Author Affiliation: Breuer M ( Unité Mixte de Recherche 7622, Centre National de la Recherche Scientifique/Université Pierre et Marie Curie, 75005 Paris, France.) |
| Abstract | In contrast to somatic cells, formation of acentriolar meiotic spindles relies on the organization of microtubules (MTs) and MT-organizing centers (MTOCs) into a stable bipolar structure. The underlying mechanisms are still unknown. We show that this process is impaired in hepatoma up-regulated protein (Hurp) knockout mice, which are viable but female sterile, showing defective oocyte divisions. HURP accumulates on interpolar MTs in the vicinity of chromosomes via Kinesin-5 activity. By promoting MT stability in the spindle central domain, HURP allows efficient MTOC sorting into distinct poles, providing bipolarity establishment and maintenance. Our results support a new model for meiotic spindle assembly in which HURP ensures assembly of a central MT array, which serves as a scaffold for the genesis of a robust bipolar structure supporting efficient chromosome congression. Furthermore, HURP is also required for the clustering of extra centrosomes before division, arguing for a shared molecular requirement of MTOC sorting in mammalian meiosis and cancer cell division. |
| ISSN | 00219525 |
| e-ISSN | 15408140 |
| Journal | The Journal of Cell Biology |
| Issue Number | 7 |
| Volume Number | 191 |
| Language | English |
| Publisher | Rockefeller University Press (United States) |
| Publisher Date | 2010-12-27 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Cell Cycle Proteins Metabolism Centrosome Meiosis Physiology Microtubule-Organizing Center Mitosis Neoplasms Pathology Spindle Apparatus Anaphase Genetics Animals Cell Line, Tumor Chromosome Segregation Gene Expression Kinesin Antagonists & Inhibitors Kinetochores Mice Mice, 129 Strain Mice, Knockout Microtubule-Associated Proteins Microtubules Oocytes RNA, Small Interfering Research Support, Non-U.S. Gov't Cell Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Medicine |
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