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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Wodarz, Andreas Honemann-capito, Mona Morawe, Tobias Von Stein, Walter |
| Description | Author Affiliation: Morawe T ( Abteilung Stammzellbiologie, Forschungszentrum der Deutschen Forschungsgemeinschaft für Molekularphysiologie des Gehirns, Georg-August-Universität Göttingen, 37077 Göttingen, Germany.) |
| Abstract | In Drosophila melanogaster oogenesis, there are 16 germline cells that form a cyst and stay connected to each other by ring canals. Ring canals allow the cytoplasmic transport of proteins, messenger ribonucleic acids, and yolk components from the nurse cells into the oocyte. In this paper, we describe the protein Rings lost (Rngo) and show that it is required for ring canal growth in germline cysts. rngo is an essential gene, and germline clones of a rngo-null allele show defects in ovary development, including mislocalization of ring canal proteins and fusion of germline cells. Rngo appears to be a ubiquitin receptor that possesses a ubiquitin-like domain, a ubiquitin-associated domain, and a retroviral-like aspartate protease (RVP) domain. Rngo binds to ubiquitin and to the 26S proteasome and colocalizes with both in germline cells, and its RVP domain is required for dimerization of Rngo and for its function in vivo. Our results thus show, for the first time, a function for a ubiquitin receptor in Drosophila development. |
| ISSN | 00219525 |
| e-ISSN | 15408140 |
| Journal | The Journal of Cell Biology |
| Issue Number | 1 |
| Volume Number | 193 |
| Language | English |
| Publisher | Rockefeller University Press (United States) |
| Publisher Date | 2011-04-04 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Drosophila Melanogaster Growth & Development Oogenesis Genetics Proteasome Endopeptidase Complex Metabolism Receptors, Cytoplasmic And Nuclear Animals Research Support, Non-U.S. Gov't Cell Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Medicine |
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