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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Birk, David E. Williams, Valerie Zwolanek, Daniela Cha, Byeong Jepsen, Karl J. Izu, Yayoi Sun, Mei Veit, Guido Koch, Manuel |
| Description | Author Affiliation: Izu Y ( Department of Pathology and Cell Biology, College of Medicine, University of South Florida, Tampa, FL 33612, USA.) |
| Abstract | Differentiated osteoblasts are polarized in regions of bone deposition, demonstrate extensive cell interaction and communication, and are responsible for bone formation and quality. Type XII collagen is a fibril-associated collagen with interrupted triple helices and has been implicated in the osteoblast response to mechanical forces. Type XII collagen is expressed by osteoblasts and localizes to areas of bone formation. A transgenic mouse null for type XII collagen exhibits skeletal abnormalities including shorter, more slender long bones with decreased mechanical strength as well as altered vertebrae structure compared with wild-type mice. $Col12a^{−/−}$ osteoblasts have decreased bone matrix deposition with delayed maturation indicated by decreased bone matrix protein expression. Compared with controls, $Col12a^{−/−}$ osteoblasts are disorganized and less polarized with disrupted cell–cell interactions, decreased connexin43 expression, and impaired gap junction function. The data demonstrate important regulatory roles for type XII collagen in osteoblast differentiation and bone matrix formation. |
| ISSN | 00219525 |
| e-ISSN | 15408140 |
| Journal | The Journal of Cell Biology |
| Issue Number | 6 |
| Volume Number | 193 |
| Language | English |
| Publisher | Rockefeller University Press (United States) |
| Publisher Date | 2011-06-13 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Cell Communication Physiology Cell Polarity Collagen Type XII Metabolism Osteoblasts Cytology Osteogenesis Animals Bone Matrix Ultrastructure Bone And Bones Anatomy & Histology Cell Differentiation Genetics Connexin 43 Mice Mice, Inbred C57BL Mice, Transgenic Stress, Mechanical Research Support, N.I.H., Extramural Cell Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Medicine |
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