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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Kerr, Gary W. Millar, Jonathan B. A. Tibbles, Katherine L. Petronczki, Mark Arumugam, Prakash Sarkar, Sourav |
| Description | Author Affiliation: Kerr GW ( University of Warwick, Coventry CV4 7AL, England, UK.) |
| Abstract | During meiosis, one round of deoxyribonucleic acid replication is followed by two rounds of nuclear division. In Saccharomyces cerevisiae, activation of the Cdc14 early anaphase release (FEAR) network is required for exit from meiosis I but does not lead to the activation of origins of replication. The precise mechanism of how FEAR regulates meiosis is not understood. In this paper, we report that premature activation of FEAR during meiosis caused by loss of protein phosphatase $PP2A^{Cdc55}$ activity blocks bipolar spindle assembly and nuclear divisions. In cdc55 meiotic null (cdc55-mn) cells, the cyclin-dependent kinase (Cdk)–counteracting phosphatase Cdc14 was released prematurely from the nucleolus concomitant with hyperphosphorylation of its nucleolar anchor protein Net1. Crucially, a mutant form of Net1 that lacks six Cdk phosphorylation sites rescued the meiotic defect of cdc55-mn cells. Expression of a dominant mutant allele of CDC14 mimicked the cdc55-mn phenotype. We propose that phosphoregulation of Net1 by $PP2A^{Cdc55}$ is essential for preventing precocious exit from meiosis I. |
| ISSN | 00219525 |
| e-ISSN | 15408140 |
| Journal | The Journal of Cell Biology |
| Issue Number | 7 |
| Volume Number | 193 |
| Language | English |
| Publisher | Rockefeller University Press (United States) |
| Publisher Date | 2011-06-27 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Cell Cycle Proteins Metabolism Physiology Cyclin-Dependent Kinases Meiosis Nuclear Proteins Protein Phosphatase 2 Saccharomyces Cerevisiae Proteins Saccharomyces Cerevisiae Cytology Binding Sites Chemistry Genetics Phosphorylation Protein Tyrosine Phosphatases Research Support, Non-U.S. Gov't Cell Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Medicine |
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