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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Lippi, Giordano Young, Kenneth W. Forsythe, Ian D. Steinert, Joern R. Schratt, Gerhard Nicotera, Pierluigi Fiore, Roberto Zoli, Michele Marczylo, Emma L. D'oro, Sabina |
| Description | Author Affiliation: Lippi G ( Medical Research Council Toxicology Unit, University of Leicester, Leicester, LE1 9HN, England, UK. glippi@ucsd.edu) |
| Abstract | Previous studies have demonstrated that microribonucleic acids (miRs) are key regulators of protein expression in the brain and modulate dendritic spine morphology and synaptic activity. To identify novel miRs involved in neuronal plasticity, we exposed adult mice to chronic treatments with nicotine, cocaine, or amphetamine, which are psychoactive drugs that induce well-documented neuroadaptations. We observed brain region– and drug-specific changes in miR expression levels and identified miR-29a/b as regulators of synaptic morphology. In vitro imaging experiments indicated that miR-29a/b reduce mushroom-shaped dendritic spines on hippocampal neurons with a concomitant increase in filopodial-like outgrowths, suggesting an effect on synapse formation via actin cytoskeleton remodeling. We identified Arpc3, a component of the ARP2/3 actin nucleation complex, as a bona fide target for down-regulation by miR-29a/b. This work provides evidence that targeting of Arpc3 by miR-29a/b fine tunes structural plasticity by regulating actin network branching in mature and developing spines. |
| ISSN | 00219525 |
| e-ISSN | 15408140 |
| Journal | The Journal of Cell Biology |
| Issue Number | 6 |
| Volume Number | 194 |
| Language | English |
| Publisher | Rockefeller University Press (United States) |
| Publisher Date | 2011-09-19 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Actin-Related Protein 2-3 Complex Metabolism Dendritic Spines MicroRNAs Genetics Actins Animals Cells, Cultured Down-Regulation Hippocampus Mice Mice, Inbred C57BL Neurons Transfection Research Support, Non-U.S. Gov't Cell Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Medicine |
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