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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Hodges, Alex R. Trybus, Kathleen M. Travaglia, Mirko Krementsova, Elena B. Sladewski, Thomas E. Bookwalter, Carol S. Sweeney, H. Lee |
| Description | Author Affiliation: Krementsova EB ( Department of Molecular Physiology and Biophysics, University of Vermont, Burlington, VT 05405, USA.) |
| Abstract | Myo4p, one of two class V myosins in budding yeast, continuously transports messenger RNA (mRNA) cargo in the cell but is nonprocessive when characterized in vitro. The adapter protein She3p tightly binds to the Myo4p rod, forming a single-headed motor complex. In this paper, we show that two Myo4p–She3p motors are recruited by the tetrameric mRNA-binding protein She2p to form a processive double-headed complex. The binding site for She3p was mapped to a single α helix that protrudes at right angles from She2p. Processive runs of several micrometers on yeast actin–tropomyosin filaments were observed only in the presence of She2p, and, thus, motor activity is regulated by cargo binding. While moving processively, each head steps ∼72 nm in a hand-over-hand motion. Coupling two high-duty cycle monomeric motors via a common cargo-binding adapter protein creates a complex with transport properties comparable with a single dimeric processive motor such as vertebrate myosin Va. |
| ISSN | 00219525 |
| e-ISSN | 15408140 |
| Journal | The Journal of Cell Biology |
| Issue Number | 4 |
| Volume Number | 195 |
| Language | English |
| Publisher | Rockefeller University Press (United States) |
| Publisher Date | 2011-11-14 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Myosin Heavy Chains Metabolism Myosin Type V RNA-Binding Proteins Saccharomyces Cerevisiae Proteins Saccharomyces Cerevisiae Models, Molecular Chemistry Protein Conformation RNA, Messenger Cytology Genetics Research Support, N.I.H., Extramural Cell Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Medicine |
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