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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Chand, Hitendra Delgado, Monica Lin, Yuting Choi, Augustine M. K. Xiang, Jialing Tesfaigzi, Yohannes Mebratu, Yohannes Ryter, Stefan W. Hu, Chien-an A. Contreras, Amelia U. Montano, Gilbert |
| Description | Author Affiliation: Contreras AU ( Chronic Obstructive Pulmonary Disease Program, Lovelace Respiratory Research Institute, Albuquerque, NM 87108, USA.) |
| Abstract | Interferon γ (IFN-γ)–induced cell death is mediated by the BH3-only domain protein, Bik, in a p53-independent manner. However, the effect of IFN-γ on p53 and how this affects autophagy have not been reported. The present study demonstrates that IFN-γ down-regulated expression of the BH3 domain-only protein, Bmf, in human and mouse airway epithelial cells in a p53-dependent manner. p53 also suppressed Bmf expression in response to other cell death–stimulating agents, including ultraviolet radiation and histone deacetylase inhibitors. IFN-γ did not affect Bmf messenger RNA half-life but increased nuclear p53 levels and the interaction of p53 with the Bmf promoter. IFN-γ–induced interaction of HDAC1 and p53 resulted in the deacetylation of p53 and suppression of Bmf expression independent of p53’s proline-rich domain. Suppression of Bmf facilitated IFN-γ–induced autophagy by reducing the interaction of Beclin-1 and Bcl-2. Furthermore, autophagy was prominent in cultured $bmf^{−/−}$ but not in $bmf^{+/+}$ cells. Collectively, these observations show that deacetylation of p53 suppresses Bmf expression and facilitates autophagy. |
| ISSN | 00219525 |
| e-ISSN | 15408140 |
| Journal | The Journal of Cell Biology |
| Issue Number | 3 |
| Volume Number | 201 |
| Language | English |
| Publisher | Rockefeller University Press (United States) |
| Publisher Date | 2013-04-29 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Adaptor Proteins, Signal Transducing Genetics Autophagy Gene Expression Protein Processing, Post-Translational Tumor Suppressor Protein P53 Metabolism Acetylation Animals Butyric Acid Pharmacology Cell Nucleus Cells, Cultured Epithelial Cells Gene Silencing Histone Deacetylase 1 Antagonists & Inhibitors Histone Deacetylase Inhibitors Hydroxamic Acids Interferon-gamma Physiology Mice Mice, 129 Strain Mice, Inbred C57BL Mice, Knockout Promoter Regions, Genetic Respiratory Mucosa Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Cell Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Medicine |
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