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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Kaback, David B. Sau, Soumitra Conrad, Michael N. Lee, Chih-ying Dresser, Michael E. Jayaram, Makkuni |
| Description | Author Affiliation: Sau S ( Department of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712.); Conrad MN ( Program in Cell Cycle and Cancer Biology, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104.); Lee CY ( Program in Cell Cycle and Cancer Biology, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104.); Kaback DB ( Department of Microbiology and Molecular Genetics, Rutgers New Jersey Medical School, Newark, NJ 07101.); Dresser ME ( Program in Cell Cycle and Cancer Biology, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104.); Jayaram M ( Department of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712 jayaram@austin.utexas.edu.) |
| Abstract | The chromosome-like mitotic stability of the yeast 2 micron plasmid is conferred by the plasmid proteins Rep1-Rep2 and the cis-acting locus STB, likely by promoting plasmid-chromosome association and segregation by hitchhiking. Our analysis reveals that stable plasmid segregation during meiosis requires the bouquet proteins Ndj1 and Csm4. Plasmid relocalization from the nuclear interior in mitotic cells to the periphery at or proximal to telomeres rises from early meiosis to pachytene. Analogous to chromosomes, the plasmid undergoes Csm4- and Ndj1-dependent rapid prophase movements with speeds comparable to those of telomeres. Lack of Ndj1 partially disrupts plasmid–telomere association without affecting plasmid colocalization with the telomere-binding protein Rap1. The plasmid appears to engage a meiosis-specific motor that orchestrates telomere-led chromosome movements for its telomere-associated segregation during meiosis I. This hitherto uncharacterized mode of germ-line transmission by a selfish genetic element signifies a mechanistic variation within the shared theme of chromosome-coupled plasmid segregation during mitosis and meiosis. |
| ISSN | 00219525 |
| e-ISSN | 15408140 |
| Journal | The Journal of Cell Biology |
| Issue Number | 5 |
| Volume Number | 205 |
| Language | English |
| Publisher | Rockefeller University Press (United States) |
| Publisher Date | 2014-06-09 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | DNA, Fungal Genetics Gene Expression Regulation, Fungal Meiosis Repetitive Sequences, Nucleic Acid Saccharomyces Cerevisiae Telomere Ultrastructure Cell Cycle Proteins Chromosome Segregation Chromosomes, Fungal Cytoskeletal Proteins Genes, Reporter Green Fluorescent Proteins Metabolism Kinetochores Membrane Proteins Mitosis Nuclear Proteins Plasmids Prophase Saccharomyces Cerevisiae Proteins Spindle Apparatus Telomere-Binding Proteins Transcription Factors Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Cell Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Medicine |
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