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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Ding, Shou-wei Wang, Xiao-hong Li, Wan-xiang Li, Hong-wei Atkinson, Peter Aliyari, Roghiyh Kim, Kevin Carthew, Richard |
| Description | Author Affiliation: Wang XH ( Graduate Program for Microbiology, University of California, Riverside, CA 92521, USA.) |
| Abstract | Innate immunity against bacterial and fungal pathogens is mediated by Toll and immune deficiency (Imd) pathways, but little is known about the antiviral response in Drosophila. Here, we demonstrate that an RNA interference pathway protects adult flies from infection by two evolutionarily diverse viruses. Our work also describes a molecular framework for the viral immunity, in which viral double-stranded RNA produced during infection acts as the pathogen trigger whereas Drosophila Dicer-2 and Argonaute-2 act as host sensor and effector, respectively. These findings establish a Drosophila model for studying the innate immunity against viruses in animals. |
| ISSN | 00368075 |
| e-ISSN | 10959203 |
| Journal | Science |
| Issue Number | 5772 |
| Volume Number | 312 |
| Language | English |
| Publisher | American Association for the Advancement of Science (United States) |
| Publisher Date | 2006-04-21 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Drosophila Melanogaster Immunology Virology Immunity, Innate Insect Viruses Physiology Nodaviridae RNA Interference Animals Argonaute Proteins Cell Line Drosophila Proteins Genetics Metabolism Embryology Embryo, Nonmammalian Escherichia Coli Micrococcus Luteus Mutation RNA Helicases RNA Viruses RNA, Double-Stranded RNA, Small Interfering RNA, Viral RNA-Binding Proteins RNA-Induced Silencing Complex Ribonuclease III Signal Transduction Toll-Like Receptors Transfection Virus Replication Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S. Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | History and Philosophy of Science |
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