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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Kim, Jae-ick Lee, Seung-hee Lee, Sue-hyun Choi, Jun-hyeok Lee, Nuribalhae Yu, Nam-kyung Kaang, Bong-kiun Choi, Sun-lim Kim, Hyoung Lee, Hye-ryeon |
| Description | Author Affiliation: Lee SH ( National Creative Research Initiative Center for Memory, Department of Biological Sciences, College of Natural Sciences, Seoul National University, San 56-1 Silim-dong, Gwanak-gu, Seoul 151-747, Korea.) |
| Abstract | Reactivated memory undergoes a rebuilding process that depends on de novo protein synthesis. This suggests that retrieval is dynamic and serves to incorporate new information into preexisting memories. However, little is known about whether or not protein degradation is involved in the reorganization of retrieved memory. We found that postsynaptic proteins were degraded in the hippocampus by polyubiquitination after retrieval of contextual fear memory. Moreover, the infusion of proteasome inhibitor into the CA1 region immediately after retrieval prevented anisomycin-induced memory impairment, as well as the extinction of fear memory. This suggests that ubiquitin- and proteasome-dependent protein degradation underlies destabilization processes after fear memory retrieval. It also provides strong evidence for the existence of reorganization processes whereby preexisting memory is disrupted by protein degradation, and updated memory is reconsolidated by protein synthesis. |
| ISSN | 00368075 |
| Issue Number | 5867 |
| Volume Number | 319 |
| e-ISSN | 10959203 |
| Journal | Science |
| Language | English |
| Publisher | American Association for the Advancement of Science (United States) |
| Publisher Date | 2008-02-29 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Fear Hippocampus Metabolism Memory Mental Recall Nerve Tissue Proteins Synapses Animals Anisomycin Pharmacology Conditioning (Psychology) Extinction, Psychological Drug Effects Lactones Male Mice Mice, Inbred C57BL Proteasome Endopeptidase Complex Protein Synthesis Inhibitors Ubiquitination Journal Article Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | History and Philosophy of Science |
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