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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Toor, Navtej Keating, Kevin S. Taylor, Sean D. Pyle, Anna Marie |
| Description | Author Affiliation: Toor N ( Department of Molecular Biophysics and Biochemistry, Yale University, 266 Whitney Avenue, Bass Building, New Haven, CT 06511, USA. navtej.toor@yale.edu) |
| Abstract | Group II introns are self-splicing ribozymes that catalyze their own excision from precursor transcripts and insertion into new genetic locations. Here we report the crystal structure of an intact, self-spliced group II intron from Oceanobacillus iheyensis at 3.1 angstrom resolution. An extensive network of tertiary interactions facilitates the ordered packing of intron subdomains around a ribozyme core that includes catalytic domain V. The bulge of domain V adopts an unusual helical structure that is located adjacent to a major groove triple helix (catalytic triplex). The bulge and catalytic triplex jointly coordinate two divalent metal ions in a configuration that is consistent with a two-metal ion mechanism for catalysis. Structural and functional analogies support the hypothesis that group II introns and the spliceosome share a common ancestor. |
| ISSN | 00368075 |
| e-ISSN | 10959203 |
| Journal | Science |
| Issue Number | 5872 |
| Volume Number | 320 |
| Language | English |
| Publisher | American Association for the Advancement of Science (United States) |
| Publisher Date | 2008-04-04 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Bacillaceae Genetics Introns RNA Splicing RNA, Bacterial Chemistry RNA, Catalytic Allosteric Regulation Base Pairing Binding Sites Catalysis Catalytic Domain Crystallography, X-Ray Evolution, Molecular Ligands Magnesium Models, Molecular Nucleic Acid Conformation Phylogeny Metabolism Spliceosomes Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | History and Philosophy of Science |
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