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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Sur, Mriganka Schummers, James Yu, Hongbo |
| Description | Author Affiliation: Schummers J ( Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.) |
| Abstract | Astrocytes have long been thought to act as a support network for neurons, with little role in information representation or processing. We used two-photon imaging of calcium signals in the ferret visual cortex in vivo to discover that astrocytes, like neurons, respond to visual stimuli, with distinct spatial receptive fields and sharp tuning to visual stimulus features including orientation and spatial frequency. The stimulus-feature preferences of astrocytes were exquisitely mapped across the cortical surface, in close register with neuronal maps. The spatially restricted stimulus-specific component of the intrinsic hemodynamic mapping signal was highly sensitive to astrocyte activation, indicating that astrocytes have a key role in coupling neuronal organization to mapping signals critical for noninvasive brain imaging. Furthermore, blocking astrocyte glutamate transporters influenced the magnitude and duration of adjacent visually driven neuronal responses. |
| ISSN | 00368075 |
| Issue Number | 5883 |
| Volume Number | 320 |
| e-ISSN | 10959203 |
| Journal | Science |
| Language | English |
| Publisher | American Association for the Advancement of Science (United States) |
| Publisher Date | 2008-06-20 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Astrocytes Physiology Neurons Visual Cortex Animals Aspartic Acid Pharmacology Drug Effects Blood Volume Brain Mapping Calcium Metabolism Calcium Signaling Cerebrovascular Circulation Ferrets Fluorescent Dyes Glutamic Acid Male Microscopy, Confocal Neurotransmitter Agents Photic Stimulation Synapses Blood Supply Cytology Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | History and Philosophy of Science |
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