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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Hunte, Carola Zickermann, Volker Brandt, Ulrich |
| Description | Author Affiliation: Hunte C ( Institute for Biochemistry and Molecular Biology, Centre for Biological Signalling Studies (BIOSS), University of Freiburg, D-79104 Freiburg, Germany.) |
| Abstract | Proton-pumping respiratory complex I is one of the largest and most complicated membrane protein complexes. Its function is critical for efficient energy supply in aerobic cells, and malfunctions are implicated in many neurodegenerative disorders. Here, we report an x-ray crystallographic analysis of mitochondrial complex I. The positions of all iron-sulfur clusters relative to the membrane arm were determined in the complete enzyme complex. The ubiquinone reduction site resides close to 30 angstroms above the membrane domain. The arrangement of functional modules suggests conformational coupling of redox chemistry with proton pumping and essentially excludes direct mechanisms. We suggest that a approximately 60-angstrom-long helical transmission element is critical for transducing conformational energy to proton-pumping elements in the distal module of the membrane arm. |
| ISSN | 00368075 |
| Issue Number | 5990 |
| Volume Number | 329 |
| e-ISSN | 10959203 |
| Journal | Science |
| Language | English |
| Publisher | American Association for the Advancement of Science (United States) |
| Publisher Date | 2010-07-23 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Electron Transport Complex I Chemistry Metabolism Mitochondrial Proteins Yarrowia Enzymology Amino Acid Sequence Binding Sites Crystallography, X-Ray Fungal Proteins Iron Mitochondria Models, Molecular Molecular Sequence Data Oxidation-Reduction Protein Conformation Protein Structure, Quaternary Protein Structure, Tertiary Protein Subunits Protons Sulfur Ubiquinone Journal Article Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | History and Philosophy of Science |
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