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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Puzio-kuter, Anna M. Levine, Arnold J. |
| Description | Author Affiliation: Levine AJ ( Institute for Advanced Study, Princeton, NJ 08540, USA. alevine@ias.edu) |
| Abstract | Cells from some tumors use an altered metabolic pattern compared with that of normal differentiated adult cells in the body. Tumor cells take up much more glucose and mainly process it through aerobic glycolysis, producing large quantities of secreted lactate with a lower use of oxidative phosphorylation that would generate more adenosine triphosphate (ATP), water, and carbon dioxide. This is the Warburg effect, which provides substrates for cell growth and division and free energy (ATP) from enhanced glucose use. This metabolic switch places the emphasis on producing intermediates for cell growth and division, and it is regulated by both oncogenes and tumor suppressor genes in a number of key cancer-producing pathways. Blocking these metabolic pathways or restoring these altered pathways could lead to a new approach in cancer treatments. |
| ISSN | 00368075 |
| Issue Number | 6009 |
| Volume Number | 330 |
| e-ISSN | 10959203 |
| Journal | Science |
| Language | English |
| Publisher | American Association for the Advancement of Science (United States) |
| Publisher Date | 2010-12-03 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Genes, Tumor Suppressor Neoplasms Genetics Metabolism Oncogenes Adenosine Triphosphate Cell Division Citric Acid Cycle Gene Expression Regulation, Neoplastic Glucose Glutamine Glycolysis Humans NADP Drug Therapy Pathology Pentose Phosphate Pathway Signal Transduction Journal Article Review Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | History and Philosophy of Science |
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