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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Kim, Nayun Kunkel, Thomas A. Huang, Shar-yin N. Williams, Jessica S. Clark, Alan B. Jinks-robertson, Sue Cho, Jang-eun Pommier, Yves Li, Yue C. |
| Description | Author Affiliation: Kim N ( Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA.) |
| Abstract | The ribonuclease (RNase) H class of enzymes degrades the RNA component of RNA:DNA hybrids and is important in nucleic acid metabolism. RNase H2 is specialized to remove single ribonucleotides [ribonucleoside monophosphates (rNMPs)] from duplex DNA, and its absence in budding yeast has been associated with the accumulation of deletions within short tandem repeats. Here, we demonstrate that rNMP-associated deletion formation requires the activity of Top1, a topoisomerase that relaxes supercoils by reversibly nicking duplex DNA. The reported studies extend the role of Top1 to include the processing of rNMPs in genomic DNA into irreversible single-strand breaks, an activity that can have distinct mutagenic consequences and may be relevant to human disease. |
| ISSN | 00368075 |
| e-ISSN | 10959203 |
| Journal | Science |
| Issue Number | 6037 |
| Volume Number | 332 |
| Language | English |
| Publisher | American Association for the Advancement of Science (United States) |
| Publisher Date | 2011-06-24 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | DNA Topoisomerases, Type I Metabolism DNA, Fungal Mutagenesis Ribonucleotides Saccharomyces Cerevisiae Genetics Sequence Deletion Amino Acid Transport Systems, Basic Camptothecin Pharmacology Canavanine DNA Breaks Chemistry DNA, Single-Stranded Microsatellite Repeats Molecular Sequence Data Nucleic Acid Conformation Ribonuclease H Enzymology Saccharomyces Cerevisiae Proteins Transcription, Genetic Research Support, N.I.H., Extramural Research Support, N.I.H., Intramural Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | History and Philosophy of Science |
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