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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Balmand, Séverine Vigneron, Aurélien Rochat, Didier Weiss-gayet, Michèle Heddi, Abdelaziz Vincent-monégat, Carole Login, Frédéric H. Vallier, Agnès |
| Description | Author Affiliation: Login FH ( INSA-Lyon, INRA, UMR203 BF2I, Biologie Fonctionnelle Insectes et Interactions, F-69621 Villeurbanne, France.) |
| Abstract | Vertically transmitted endosymbionts persist for millions of years in invertebrates and play an important role in animal evolution. However, the functional basis underlying the maintenance of these long-term resident bacteria is unknown. We report that the weevil coleoptericin-A (ColA) antimicrobial peptide selectively targets endosymbionts within the bacteriocytes and regulates their growth through the inhibition of cell division. Silencing the colA gene with RNA interference resulted in a decrease in size of the giant filamentous endosymbionts, which escaped from the bacteriocytes and spread into insect tissues. Although this family of peptides is commonly linked with microbe clearance, this work shows that endosymbiosis benefits from ColA, suggesting that long-term host-symbiont coevolution might have shaped immune effectors for symbiont maintenance. |
| ISSN | 00368075 |
| Issue Number | 6054 |
| Volume Number | 334 |
| e-ISSN | 10959203 |
| Journal | Science |
| Language | English |
| Publisher | American Association for the Advancement of Science (United States) |
| Publisher Date | 2011-10-21 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Gammaproteobacteria Physiology Insect Proteins Metabolism Symbiosis Weevils Microbiology Animals Bacterial Outer Membrane Proteins Bacterial Proteins Chaperonin 60 Genetics Cytoplasm Epithelial Cells Escherichia Coli Cytology Drug Effects Fat Body Pharmacology Micrococcus Luteus Oocytes RNA Interference Saccharomyces Cerevisiae Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | History and Philosophy of Science |
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