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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Elsaesser, Heidi Wilson, Elizabeth B. Herskovitz, Jonathan Karp, Christopher L. Yamada, Douglas H. Cheng, Genhong Deng, Jane Aronow, Bruce J. Brooks, David G. |
| Description | Author Affiliation: Wilson EB ( Department of Microbiology, Immunology and Molecular Genetics and the UCLA AIDS Institute, David Geffen School of Medicine, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA.) |
| Abstract | Type I interferons (IFN-I) are critical for antiviral immunity; however, chronic IFN-I signaling is associated with hyperimmune activation and disease progression in persistent infections. We demonstrated in mice that blockade of IFN-I signaling diminished chronic immune activation and immune suppression, restored lymphoid tissue architecture, and increased immune parameters associated with control of virus replication, ultimately facilitating clearance of the persistent infection. The accelerated control of persistent infection induced by blocking IFN-I signaling required CD4 T cells and was associated with enhanced IFN-γ production. Thus, we demonstrated that interfering with chronic IFN-I signaling during persistent infection redirects the immune environment to enable control of infection. |
| ISSN | 00368075 |
| e-ISSN | 10959203 |
| Journal | Science |
| Issue Number | 6129 |
| Volume Number | 340 |
| Language | English |
| Publisher | American Association for the Advancement of Science (United States) |
| Publisher Date | 2013-04-12 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Arenaviridae Infections Immunology Virology Interferon Type I Metabolism Lymphocytic Choriomeningitis Virus Physiology Signal Transduction Animals Antibodies Antigens, CD274 CD4-Positive T-Lymphocytes Cytokines Dendritic Cells Gene Expression Profiling Immune Tolerance Genetics Interferon-gamma Interleukin-10 Mice Oligonucleotide Array Sequence Analysis Receptor, Interferon Alpha-beta Antagonists & Inhibitors Virus Replication Research Support, N.I.H., Extramural Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | History and Philosophy of Science |
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