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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Keller, Philipp J. |
| Description | Author Affiliation: Keller PJ ( Howard Hughes Medical Institute, Janelia Farm Research Campus, Ashburn, VA 20147, USA. kellerp@janelia.hhmi.org) |
| Abstract | Morphogenesis, the development of the shape of an organism, is a dynamic process on a multitude of scales, from fast subcellular rearrangements and cell movements to slow structural changes at the whole-organism level. Live-imaging approaches based on light microscopy reveal the intricate dynamics of this process and are thus indispensable for investigating the underlying mechanisms. This Review discusses emerging imaging techniques that can record morphogenesis at temporal scales from seconds to days and at spatial scales from hundreds of nanometers to several millimeters. To unlock their full potential, these methods need to be matched with new computational approaches and physical models that help convert highly complex image data sets into biological insights. |
| ISSN | 00368075 |
| Issue Number | 6137 |
| Volume Number | 340 |
| e-ISSN | 10959203 |
| Journal | Science |
| Language | English |
| Publisher | American Association for the Advancement of Science (United States) |
| Publisher Date | 2013-06-07 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Image Processing, Computer-Assisted Methods Microscopy Morphogenesis Animals Drosophila Embryology Mice Models, Biological Zebrafish Journal Article Research Support, Non-U.S. Gov't Review Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | History and Philosophy of Science |
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