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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Muehlbauer, Michael J. Faith, Jeremiah J. Rey, Federico E. Knight, Rob Walters, William A. Ridaura, Vanessa K. Martini, Margaret C. Henrissat, Bernard Van Treuren, William Cheng, Jiye Duncan, Alexis E. Hayashi, David K. Ursell, Luke K. Griffin, Nicholas W. Kau, Andrew L. Bain, James R. Newgard, Christopher B. Funai, Katsuhiko Ilkayeva, Olga Heath, Andrew C. Clemente, Jose C. Lombard, Vincent Gordon, Jeffrey I. Semenkovich, Clay F. Lyle, Barbara J. |
| Description | Author Affiliation: Ridaura VK ( Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO 63108, USA.) |
| Abstract | The role of specific gut microbes in shaping body composition remains unclear. We transplanted fecal microbiota from adult female twin pairs discordant for obesity into germ-free mice fed low-fat mouse chow, as well as diets representing different levels of saturated fat and fruit and vegetable consumption typical of the U.S. diet. Increased total body and fat mass, as well as obesity-associated metabolic phenotypes, were transmissible with uncultured fecal communities and with their corresponding fecal bacterial culture collections. Cohousing mice harboring an obese twin's microbiota (Ob) with mice containing the lean co-twin's microbiota (Ln) prevented the development of increased body mass and obesity-associated metabolic phenotypes in Ob cage mates. Rescue correlated with invasion of specific members of Bacteroidetes from the Ln microbiota into Ob microbiota and was diet-dependent. These findings reveal transmissible, rapid, and modifiable effects of diet-by-microbiota interactions. |
| ISSN | 00368075 |
| e-ISSN | 10959203 |
| Journal | Science |
| Issue Number | 6150 |
| Volume Number | 341 |
| Language | English |
| Publisher | American Association for the Advancement of Science (United States) |
| Publisher Date | 2013-09-06 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Adiposity Bacteroidetes Physiology Gastrointestinal Tract Microbiology Metagenome Obesity Metabolism Animals Genetics Cecum Diet, Fat-Restricted Feces Germ-Free Life Metabolome Mice Mice, Inbred C57BL Mice, Obese Thinness Weight Gain Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Twin Study Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | History and Philosophy of Science |
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