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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Zhang, Zhihong Zhao, Hongwei Weiberg, Arne Lin, Feng-mao Kaloshian, Isgouhi Huang, Hsien-da Jin, Hailing Wang, Ming |
| Description | Author Affiliation: Weiberg A ( Department of Plant Pathology and Microbiology, University of California, Riverside, CA 92521, USA.) |
| Abstract | Botrytis cinerea, the causative agent of gray mold disease, is an aggressive fungal pathogen that infects more than 200 plant species. Here, we show that some B. cinerea small RNAs (Bc-sRNAs) can silence Arabidopsis and tomato genes involved in immunity. These Bc-sRNAs hijack the host RNA interference (RNAi) machinery by binding to Arabidopsis Argonaute 1 (AGO1) and selectively silencing host immunity genes. The Arabidopsis ago1 mutant exhibits reduced susceptibility to B. cinerea, and the B. cinerea dcl1 dcl2 double mutant that can no longer produce these Bc-sRNAs displays reduced pathogenicity on Arabidopsis and tomato. Thus, this fungal pathogen transfers 'virulent' sRNA effectors into host plant cells to suppress host immunity and achieve infection, which demonstrates a naturally occurring cross-kingdom RNAi as an advanced virulence mechanism. |
| ISSN | 00368075 |
| e-ISSN | 10959203 |
| Journal | Science |
| Issue Number | 6154 |
| Volume Number | 342 |
| Language | English |
| Publisher | American Association for the Advancement of Science (United States) |
| Publisher Date | 2013-10-04 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Arabidopsis Immunology Botrytis Pathogenicity Host-Pathogen Interactions Plant Diseases Microbiology RNA Interference RNA, Fungal Genetics RNA, Small Interfering Arabidopsis Proteins Argonaute Proteins Gene Expression Regulation, Plant Lycopersicon Esculentum Mutation Virulence Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | History and Philosophy of Science |
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