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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Tran, May Yoshida, Aya C. Kikuchi, Satomi S. Ogawa, Masaharu Matsui, Asuka Shimogori, Tomomi Mami, U. |
| Description | Author Affiliation: Matsui A ( RIKEN Brain Science Institute, Laboratory for Molecular Mechanisms of Thalamus Development, 2-1 Hirosawa Wako, Saitama 351-0198, Japan.) |
| Abstract | Experience-dependent structural changes in the developing brain are fundamental for proper neural circuit formation. Here, we show that during the development of the sensory cortex, dendritic field orientation is controlled by the BTB/POZ domain-containing 3 (BTBD3). In developing mouse somatosensory cortex, endogenous Btbd3 translocated to the cell nucleus in response to neuronal activity and oriented primary dendrites toward active axons in the barrel hollow. Btbd3 also directed dendrites toward active axon terminals when ectopically expressed in mouse visual cortex or normally expressed in ferret visual cortex. BTBD3 regulation of dendrite orientation is conserved across species and cortical areas and shows how high-acuity sensory function may be achieved by the tuning of subcellular polarity to sources of high sensory activity. |
| ISSN | 00368075 |
| Issue Number | 6162 |
| Volume Number | 342 |
| e-ISSN | 10959203 |
| Journal | Science |
| Language | English |
| Publisher | American Association for the Advancement of Science (United States) |
| Publisher Date | 2013-11-29 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Axons Physiology Cell Polarity Dendrites Neocortex Embryology Nerve Net Growth & Development Nerve Tissue Proteins Metabolism Visual Cortex Active Transport, Cell Nucleus Animals Cell Nucleus Cells, Cultured Ferrets Gene Knockdown Techniques Mice Mice, Mutant Strains Genetics Journal Article Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | History and Philosophy of Science |
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