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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Ha, Taekjip Balasubramanian, Divya Singh, Digvijay Zhang, Qiucen Golding, Ido Park, Seongjin Fei, Jingyi Vanderpool, Carin K. |
| Description | Author Affiliation: Fei J ( Center for the Physics of Living Cells, Department of Physics, University of Illinois, Urbana, IL, USA.); Singh D ( Center for Biophysics and Computational Biology, University of Illinois, Urbana, IL, USA.); Zhang Q ( Center for the Physics of Living Cells, Department of Physics, University of Illinois, Urbana, IL, USA.); Park S ( Center for the Physics of Living Cells, Department of Physics, University of Illinois, Urbana, IL, USA.); Balasubramanian D ( Department of Microbiology, University of Illinois, Urbana, IL, USA.); Golding I ( Center for the Physics of Living Cells, Department of Physics, University of Illinois, Urbana, IL, USA. Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX, USA.); Vanderpool CK ( Department of Microbiology, University of Illinois, Urbana, IL, USA. tjha@illinois.edu cvanderp@life.uiuc.edu.); Ha T ( Center for the Physics of Living Cells, Department of Physics, University of Illinois, Urbana, IL, USA. Center for Biophysics and Computational Biology, University of Illinois, Urbana, IL, USA. Carl R. Woese Institute for Genomic Biology, Howard Hughes Medical Institute, Urbana, IL, USA. Howard Hugh) |
| Abstract | Base-pairing interactions between nucleic acids mediate target recognition in many biological processes. We developed a super-resolution imaging and modeling platform that enabled the in vivo determination of base pairing-mediated target recognition kinetics. We examined a stress-induced bacterial small RNA, SgrS, which induces the degradation of target messenger RNAs (mRNAs). SgrS binds to a primary target mRNA in a reversible and dynamic fashion, and formation of SgrS-mRNA complexes is rate-limiting, dictating the overall regulation efficiency in vivo. Examination of a secondary target indicated that differences in the target search kinetics contribute to setting the regulation priority among different target mRNAs. This super-resolution imaging and analysis approach provides a conceptual framework that can be generalized to other small RNA systems and other target search processes. |
| ISSN | 00368075 |
| e-ISSN | 10959203 |
| Journal | Science |
| Issue Number | 6228 |
| Volume Number | 347 |
| Language | English |
| Publisher | American Association for the Advancement of Science (United States) |
| Publisher Date | 2015-03-20 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Base Pairing Molecular Imaging RNA Stability RNA, Messenger Chemistry RNA, Small Untranslated Endoribonucleases Genetics Escherichia Coli Metabolism Kinetics Mutation Phosphoenolpyruvate Sugar Phosphotransferase System Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | History and Philosophy of Science |
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