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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Vernon, Suzanne D. Ruxrungtham, Kiat Chung, Raymond T. Xu, Qikai Larman, H. Benjamin Xu, George J. Brander, Christian Sanchez, Jorge Walker, Bruce Li, Mamie Z. Kula, Tomasz Elledge, Stephen J. Ndung'u, Thumbi O'connor, Kevin C. |
| Description | Author Affiliation: Xu GJ ( Program in Biophysics, Harvard University, Cambridge, MA 02115, USA. Harvard-Massachusetts Institute of Technology (MIT) Division of Health Sciences and Technology, Cambridge, MA 02139, USA. Division of Genetics, Department of Medicine, Howard Hughes Medical Institute, Brigham and Women's Hospital,); Kula T ( Division of Genetics, Department of Medicine, Howard Hughes Medical Institute, Brigham and Women's Hospital, Boston, MA 02115, USA. Department of Genetics, Harvard University Medical School, Boston, MA 02115, USA. Program in Biological and Biomedical Sciences, Harvard University, Cambridge, MA 02115); Xu Q ( Division of Genetics, Department of Medicine, Howard Hughes Medical Institute, Brigham and Women's Hospital, Boston, MA 02115, USA. Department of Genetics, Harvard University Medical School, Boston, MA 02115, USA.); Li MZ ( Division of Genetics, Department of Medicine, Howard Hughes Medical Institute, Brigham and Women's Hospital, Boston, MA 02115, USA. Department of Genetics, Harvard University Medical School, Boston, MA 02115, USA.); Vernon SD ( Solve ME/CFS Initiative, Los Angeles, CA 90036, USA.); Ndung'u T ( KwaZulu-Natal Research Institute for Tuberculosis and HIV, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa. HIV Pathogenesis Programme, Doris Duke Medical Research Institute, Nelson R. Mandela School of Medicine, Durban, South Africa. Ragon Institute of Massac); Ruxrungtham K ( Vaccine and Cellular Immunology Laboratory, Department of Medicine, Faculty of Medicine); Sanchez J ( Asociación Civil IMPACTA Salud y Educación, Lima, Peru.); Brander C ( AIDS Research Institute-IrsiCaixa and AIDS Unit, Hospital Germans Trias i Pujol, Universitat Autònoma de Barcelona, Badalona, Spain Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain.); Chung RT ( Division of Gastroenterology, Massachusetts General Hospital, Boston, MA 02114, USA.); O'Connor KC ( Department of Neurology, Yale School of Medicine, New Haven, CT 06520, USA.); Walker B ( HIV Pathogenesis Programme, Doris Duke Medical Research Institute, Nelson R. Mandela School of Medicine, Durban, South Africa. Ragon Institute of Massachusetts General Hospital, MIT, and Harvard University, Cambridge, MA 02139, USA.); Larman HB ( Division of Immunology, Department of Pathology, Johns Hopkins University, Baltimore, MD 21205, USA.); Elledge SJ ( Division of Genetics, Department of Medicine, Howard Hughes Medical Institute, Brigham and Women's Hospital, Boston, MA 02115, USA. Department of Genetics, Harvard University Medical School, Boston, MA 02115, USA. Solve ME/CFS Initiative, Los Angeles, CA 90036, USA. selledge@genetics.med.harvard.edu) |
| Abstract | The human virome plays important roles in health and immunity. However, current methods for detecting viral infections and antiviral responses have limited throughput and coverage. Here, we present VirScan, a high-throughput method to comprehensively analyze antiviral antibodies using immunoprecipitation and massively parallel DNA sequencing of a bacteriophage library displaying proteome-wide peptides from all human viruses. We assayed over 10(8) antibody-peptide interactions in 569 humans across four continents, nearly doubling the number of previously established viral epitopes. We detected antibodies to an average of 10 viral species per person and 84 species in at least two individuals. Although rates of specific virus exposure were heterogeneous across populations, antibody responses targeted strongly conserved 'public epitopes' for each virus, suggesting that they may elicit highly similar antibodies. VirScan is a powerful approach for studying interactions between the virome and the immune system. |
| ISSN | 00368075 |
| e-ISSN | 10959203 |
| Journal | Science |
| Issue Number | 6239 |
| Volume Number | 348 |
| Language | English |
| Publisher | American Association for the Advancement of Science (United States) |
| Publisher Date | 2015-06-05 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Antibodies, Viral Blood Epitopes, B-Lymphocyte Immunology Host-Pathogen Interactions Immune System Virology Virus Diseases Diagnosis Viruses Genetics High-Throughput Nucleotide Sequencing Immunoprecipitation Peptide Library Serologic Tests Evaluation Studies Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | History and Philosophy of Science |
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