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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Tsugane, Shoichiro Yuan, Jian-min Gao, Yu-tang Gupta, Prakash Chandra Irie, Fujiko Yang, Gong You, San-lin Inoue, Manami Chen, Chien-jen Pednekar, Mangesh Suryakant Shen, Chen-yang Mclerran, Dale F. Zhang, Xianglan Xiang, Yong-bing Zheng, Wei Koh, Woon-puay Kang, Daehee Ahsan, Habibul Suzuki, Takeshi Nagai, Masato Tsuji, Ichiro Wang, Renwei Sairenchi, Toshimi Tanaka, Hideo Yoo, Keun-young Park, Sue K. Ramadas, Kunnambath Potter, John D. Sasazuki, Shizuka Chen, Yu He, Jiang Sauvaget, Catherine Feng, Ziding Thornquist, Mark Boffetta, Paolo Shu, Xiao-ou Gu, Dongfeng Tamakoshi, Akiko Pan, Wen-harn Matsuo, Keitaro Kuriyama, Shinichi Nishino, Yoshikazu Rolland, Betsy Satoh, Hiroshi |
| Spatial Coverage | Asia |
| Description | Author Affiliation: Zheng W ( Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, VanderbiltIngram Cancer Center, Vanderbilt University, Nashville, TN, USA. wei.zheng@vanderbilt.edu) |
| Abstract | BACKGROUND: Most studies that have evaluated the association between the body-mass index (BMI) and the risks of death from any cause and from specific causes have been conducted in populations of European origin. METHODS: We performed pooled analyses to evaluate the association between BMI and the risk of death among more than 1.1 million persons recruited in 19 cohorts in Asia. The analyses included approximately 120,700 deaths that occurred during a mean follow-up period of 9.2 years. Cox regression models were used to adjust for confounding factors. RESULTS: In the cohorts of East Asians, including Chinese, Japanese, and Koreans, the lowest risk of death was seen among persons with a BMI (the weight in kilograms divided by the square of the height in meters) in the range of 22.6 to 27.5. The risk was elevated among persons with BMI levels either higher or lower than that range--by a factor of up to 1.5 among those with a BMI of more than 35.0 and by a factor of 2.8 among those with a BMI of 15.0 or less. A similar U-shaped association was seen between BMI and the risks of death from cancer, from cardiovascular diseases, and from other causes. In the cohorts comprising Indians and Bangladeshis, the risks of death from any cause and from causes other than cancer or cardiovascular disease were increased among persons with a BMI of 20.0 or less, as compared with those with a BMI of 22.6 to 25.0, whereas there was no excess risk of either death from any cause or cause-specific death associated with a high BMI. CONCLUSIONS: Underweight was associated with a substantially increased risk of death in all Asian populations. The excess risk of death associated with a high BMI, however, was seen among East Asians but not among Indians and Bangladeshis. |
| ISSN | 00284793 |
| e-ISSN | 15334406 |
| Journal | New England Journal of Medicine |
| Issue Number | 8 |
| Volume Number | 364 |
| Language | English |
| Publisher | Massachusetts Medical Society (United States) |
| Publisher Date | 2011-02-24 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Asian Continental Ancestry Group Body Mass Index Mortality Obesity Ethnology Epidemiology Cause Of Death Cohort Studies Proportional Hazards Models Medicine |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine |
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