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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Wang, Xian-jun Liang, Mi-fang Guan, Xu-hua Kan, Biao Zhang, Lihong Hai, Rong Dong, Xiao-ping Zhan, Fa-xian Yin, Wen-wu Zhang, Yu Zhang, Yan-ping Li, Jian-dong Li, De-xin Zhou, Hang Zhang, Shou-yin Fu, Xiu-ping Sun, Yu-lan Popov, Vsevolod L. Yu, Xue-jie Wang, Hua Song, Jing-dong Wan, Kang-lin Zhao, Zhuo Hong, Tao Jing, Huai-qi Qu, Jing Wang, Yu Bi, Zhen-qiang Sun, Li-na Wu, Wei Liu, Guo-hua Zhang, Jing-shan Zhang, Quan-fu He, Jin-rong Liu, Yan Ren, Jun Liu, Jia-fa Feng, Zi-jian Li, Chuan Wan, Tao Li, Qun Wang, Shi-wen Lu, Jin-xin Yang, Wei-zhong Wang, Qin Walker, David H. |
| Spatial Coverage | China |
| Description | Author Affiliation: Yu XJ ( Chinese Center for Disease Control and Prevention, Beijing, China.) |
| Abstract | BACKGROUND: Heightened surveillance of acute febrile illness in China since 2009 has led to the identification of a severe fever with thrombocytopenia syndrome (SFTS) with an unknown cause. Infection with Anaplasma phagocytophilum has been suggested as a cause, but the pathogen has not been detected in most patients on laboratory testing. METHODS: We obtained blood samples from patients with the case definition of SFTS in six provinces in China. The blood samples were used to isolate the causal pathogen by inoculation of cell culture and for detection of viral RNA on polymerase-chain-reaction assay. The pathogen was characterized on electron microscopy and nucleic acid sequencing. We used enzyme-linked immunosorbent assay, indirect immunofluorescence assay, and neutralization testing to analyze the level of virus-specific antibody in patients' serum samples. RESULTS: We isolated a novel virus, designated SFTS bunyavirus, from patients who presented with fever, thrombocytopenia, leukocytopenia, and multiorgan dysfunction. RNA sequence analysis revealed that the virus was a newly identified member of the genus phlebovirus in the Bunyaviridae family. Electron-microscopical examination revealed virions with the morphologic characteristics of a bunyavirus. The presence of the virus was confirmed in 171 patients with SFTS from six provinces by detection of viral RNA, specific antibodies to the virus in blood, or both. Serologic assays showed a virus-specific immune response in all 35 pairs of serum samples collected from patients during the acute and convalescent phases of the illness. CONCLUSIONS: A novel phlebovirus was identified in patients with a life-threatening illness associated with fever and thrombocytopenia in China. (Funded by the China Mega-Project for Infectious Diseases and others.). |
| ISSN | 00284793 |
| e-ISSN | 15334406 |
| Journal | New England Journal of Medicine |
| Issue Number | 16 |
| Volume Number | 364 |
| Language | English |
| Publisher | Massachusetts Medical Society (United States) |
| Publisher Date | 2011-04-21 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Bunyaviridae Infections Virology Communicable Diseases, Emerging Orthobunyavirus Isolation & Purification Thrombocytopenia Animals Antibodies, Viral Blood Complications Epidemiology Fever Genome, Viral Ixodidae Microscopy, Electron, Transmission Classification Genetics Immunology Phylogeny RNA, Viral Reverse Transcriptase Polymerase Chain Reaction Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Medicine |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine |
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