NDLI: Vaccine-derived poliomyelitis 12 years after infection in Minnesota.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Lynfield, Ruth Cebelinski, Elizabeth Lexau, Catherine Christensen, Jaime Wallace, Gregory S. Bahta, Lynn Kline, Susan Devries, Aaron S. Burns, Cara C. Fuller, Susan Murray, Andrew Harper, Jane Shaw, Jing H.
Description	Author Affiliation: DeVries AS ( Minnesota Department of Health, St. Paul, MN 55164, USA. aaron.devries@state.mn.us)
Abstract	A 44-year-old woman with long-standing common variable immunodeficiency who was receiving intravenous immune globulin suddenly had paralysis of all four limbs and the respiratory muscles, resulting in death. Type 2 vaccine-derived poliovirus was isolated from stool. The viral capsid protein VP1 region had diverged from the vaccine strain at 12.3% of nucleotide positions, and the two attenuating substitutions had reverted to the wild-type sequence. Infection probably occurred 11.9 years earlier (95% confidence interval [CI], 10.9 to 13.2), when her child received the oral poliovirus vaccine. No secondary cases were identified among close contacts or 2038 screened health care workers. Patients with common variable immunodeficiency can be chronically infected with poliovirus, and poliomyelitis can develop despite treatment with intravenous immune globulin.
ISSN	00284793
Issue Number	24
Volume Number	364
e-ISSN	15334406
Journal	New England Journal of Medicine
Language	English
Publisher	Massachusetts Medical Society (United States)
Publisher Date	2011-06-16
Publisher Place	United States
Access Restriction	Subscribed
Subject Keyword	Common Variable Immunodeficiency Complications Infectious Disease Incubation Period Poliomyelitis Etiology Poliovirus Vaccine, Oral Adverse Effects Poliovirus Isolation & Purification Adult Amino Acid Sequence Fatal Outcome Feces Virology Female Humans Magnetic Resonance Imaging Diagnosis Genetics Immunology Sequence Alignment Spinal Cord Pathology Case Reports Journal Article Research Support, U.S. Gov't, P.H.S. Medicine
Content Type	Text
Resource Type	Article
Subject	Medicine

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