NDLI: Kidney-Failure Risk Projection for the Living Kidney-Donor Candidate.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Chang, Alex R. Grams, Morgan E. Nadkarni, Girish N. Sang, Yingying Coresh, Josef Ballew, Shoshana Shalev, Varda Levey, Andrew S. Chow, Eric K. H. Kovesdy, Csaba P. Garg, Amit X. Matsushita, Kunihiro Segev, Dorry L. Lentine, Krista L. Kasiske, Bertram L.
Organization	Chronic Kidney Disease Prognosis Consortium
Spatial Coverage	United States
Description	Author Affiliation: Grams ME ( From the Division of Nephrology, Johns Hopkins University School of Medicine (M.E.G.), the Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health (M.E.G., Y.S., K.M., S.B., J.C.), and the Departments of Surgery and Epidemiology, Johns Hopkins University (E.K.H.C., D.L.S.) - all in Baltimore)
Abstract	BACKGROUND: Evaluation of candidates to serve as living kidney donors relies on screening for individual risk factors for end-stage renal disease (ESRD). To support an empirical approach to donor selection, we developed a tool that simultaneously incorporates multiple health characteristics to estimate a person's probable long-term risk of ESRD if that person does not donate a kidney. METHODS: We used risk associations from a meta-analysis of seven general population cohorts, calibrated to the population-level incidence of ESRD and mortality in the United States, to project the estimated long-term incidence of ESRD among persons who do not donate a kidney, according to 10 demographic and health characteristics. We then compared 15-year projections with the observed risk among 52,998 living kidney donors in the United States. RESULTS: A total of 4,933,314 participants from seven cohorts were followed for a median of 4 to 16 years. For a 40-year-old person with health characteristics that were similar to those of age-matched kidney donors, the 15-year projections of the risk of ESRD in the absence of donation varied according to race and sex; the risk was 0.24% among black men, 0.15% among black women, 0.06% among white men, and 0.04% among white women. Risk projections were higher in the presence of a lower estimated glomerular filtration rate, higher albuminuria, hypertension, current or former smoking, diabetes, and obesity. In the model-based lifetime projections, the risk of ESRD was highest among persons in the youngest age group, particularly among young blacks. The 15-year observed risks after donation among kidney donors in the United States were 3.5 to 5.3 times as high as the projected risks in the absence of donation. CONCLUSIONS: Multiple demographic and health characteristics may be used together to estimate the projected long-term risk of ESRD among living kidney-donor candidates and to inform acceptance criteria for kidney donors. (Funded by the National Institute of Diabetes and Digestive and Kidney Diseases and others.).
ISSN	00284793
e-ISSN	15334406
Journal	New England Journal of Medicine
Issue Number	5
Volume Number	374
Language	English
Publisher	Massachusetts Medical Society (United States)
Publisher Date	2016-02-04
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Kidney Failure, Chronic Epidemiology Kidney Transplantation Living Donors Risk Assessment Glomerular Filtration Rate Hypertension Ethnology Surgery Models, Statistical Risk Factors Sex Factors Meta-Analysis Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Medicine
Content Type	Text
Resource Type	Article
Subject	Medicine

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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