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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Hernandez, Nouria Shanmugam, Mayilvahanan |
| Description | Author Affiliation: Shanmugam M ( Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.) |
| Abstract | The small nuclear RNA-activating protein complex $SNAP_{c}$ is required for transcription of small nuclear RNA genes and binds to a proximal sequence element in their promoters. $SNAP_{c}$ contains five types of subunits stably associated with each other. Here we show that one of these polypeptides, SNAP45, also known as PTF δ, localizes to centrosomes during parts of mitosis, as well as to the spindle midzone during anaphase and the mid-body during telophase. Consistent with localization to these mitotic structures, both down- and up-regulation of SNAP45 lead to a $G_{2}/M$ arrest with cells displaying abnormal mitotic structures. In contrast, down-regulation of SNAP190, another $SNAP_{c}$ subunit, leads to an accumulation of cells with a $G_{0}/G_{1}$ DNA content. These results are consistent with the proposal that SNAP45 plays two roles in the cell, one as a subunit of the transcription factor $SNAP_{c}$ and another as a factor required for proper mitotic progression. |
| ISSN | 00219258 |
| e-ISSN | 1083351X |
| Journal | Journal of Biological Chemistry |
| Issue Number | 21 |
| Volume Number | 283 |
| Language | English |
| Publisher | American Society for Biochemistry and Molecular Biology (United States) |
| Publisher Date | 2008-05-23 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Mitosis Transcription Factors Metabolism Antibodies Immunology CDC2 Protein Kinase Centrosome Cyclin B Down-Regulation HeLa Cells Protein Binding Genetics Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Biochemistry Molecular Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Biochemistry Molecular Biology |
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