NDLI: An essential ligand-binding domain in the membrane receptor for retinol-binding protein revealed by large-scale mutagenesis and a human polymorphism.

Please wait, while we are loading the content...

Year: 2017 Volume: 292

Year: 2016 Volume: 291

Year: 2015 Volume: 290

Year: 2014 Volume: 289

Year: 2013 Volume: 288

Year: 2012 Volume: 287

Year: 2011 Volume: 286

Year: 2010 Volume: 285

Year: 2009 Volume: 284

Year: 2008 Volume: 283

Year: 2008 Volume: 283 Issue: 52

Year: 2008 Volume: 283 Issue: 51

Year: 2008 Volume: 283 Issue: 50

Year: 2008 Volume: 283 Issue: 49

Year: 2008 Volume: 283 Issue: 48

Year: 2008 Volume: 283 Issue: 47

Year: 2008 Volume: 283 Issue: 46

Year: 2008 Volume: 283 Issue: 45

Year: 2008 Volume: 283 Issue: 44

Year: 2008 Volume: 283 Issue: 43

Year: 2008 Volume: 283 Issue: 42

Year: 2008 Volume: 283 Issue: 41

Year: 2008 Volume: 283 Issue: 40

Year: 2008 Volume: 283 Issue: 39

Year: 2008 Volume: 283 Issue: 38

Year: 2008 Volume: 283 Issue: 37

Year: 2008 Volume: 283 Issue: 36

Year: 2008 Volume: 283 Issue: 35

Year: 2008 Volume: 283 Issue: 34

Year: 2008 Volume: 283 Issue: 33

Year: 2008 Volume: 283 Issue: 32

Year: 2008 Volume: 283 Issue: 31

Year: 2008 Volume: 283 Issue: 30

Year: 2008 Volume: 283 Issue: 29

Year: 2008 Volume: 283 Issue: 28

Year: 2008 Volume: 283 Issue: 27

Year: 2008 Volume: 283 Issue: 26

Year: 2008 Volume: 283 Issue: 25

Year: 2008 Volume: 283 Issue: 24

Year: 2008 Volume: 283 Issue: 23

Year: 2008 Volume: 283 Issue: 22

Voltage Gating at the Selectivity Filter of the $Ca^{2+}$ Release-activated $Ca^{2+}$ Channel Induced by Mutation of the Orai1 Protein

In vitro activation of the IkappaB kinase complex by human T-cell leukemia virus type-1 Tax.

Redefining the role of metallothionein within the injured brain: extracellular metallothioneins play an important role in the astrocyte-neuron response to injury.

Miniaturization of scorpion beta-toxins uncovers a putative ancestral surface of interaction with voltage-gated sodium channels.

Investigating the regulation of brain-specific kinases 1 and 2 by phosphorylation.

Cysteine 62 of Bax Is Critical for Its Conformational Activation and Its Proapoptotic Activity in Response to $H_{2}O_{2}-induced$ Apoptosis

The lymphotoxin-beta receptor is an upstream activator of NF-kappaB-mediated transcription in melanoma cells.

E2F1 regulates the base excision repair gene XRCC1 and promotes DNA repair.

Crystal structure of Escherichia coli MazG, the regulator of nutritional stress response.

Protein Kinase Cθ Is Required for Autophagy in Response to Stress in the Endoplasmic Reticulum

Mapping of POP1-binding Site on Pyrin Domain of ASC

Requirements for Two Proximal NF-κB Binding Sites and IκB-ζ in IL-17A-induced Human β-Defensin 2 Expression by Conducting Airway $Epithelium^{*}$

A composite role of vitronectin and urokinase in the modulation of cell morphology upon expression of the urokinase receptor.

Peroxisomes as Novel Players in Cell Calcium Homeostasis

A histidine-rich and cysteine-rich metal-binding domain at the C terminus of heat shock protein A from Helicobacter pylori: implication for nickel homeostasis and bismuth susceptibility.

I SA channel complexes include four subunits each of DPP6 and Kv4.2.

Structural and biophysical characterization of human myo-inositol oxygenase.

X-ray structure of 4,4'-dihydroxybenzophenone mimicking sterol substrate in the active site of sterol 14alpha-demethylase (CYP51).

Direct monitoring of allosteric recognition of type IIE restriction endonuclease EcoRII.

Reaction mechanism and structural model of ADP-forming Acetyl-CoA synthetase from the hyperthermophilic archaeon Pyrococcus furiosus: evidence for a second active site histidine residue.

Interaction of HIV-1 gp41 core with NPF motif in Epsin: implication in endocytosis of HIV.

Glial cell aquaporin-4 overexpression in transgenic mice accelerates cytotoxic brain swelling.

3-Isobutylmethylxanthine Inhibits Hepatic Urea Synthesis: PROTECTION BY AGMATINE

In search of the message.

Increased Cross-bridge Cycling Kinetics after Exchange of C-terminal Truncated Troponin I in Skinned Rat Cardiac Muscle

Noonan syndrome-associated SHP-2/Ptpn11 mutants enhance SIRPalpha and PZR tyrosyl phosphorylation and promote adhesion-mediated ERK activation.

The LIM-only protein FHL2 regulates cyclin D1 expression and cell proliferation.

Cooperative regulation of Fc receptor gamma-chain gene expression by multiple transcription factors, including Sp1, GABP, and Elf-1.

Kinetic investigation of the inhibitory effect of gemcitabine on DNA polymerization catalyzed by human mitochondrial DNA polymerase.

The HIV-1 envelope glycoprotein gp120 features four heparan sulfate binding domains, including the co-receptor binding site.

Oxidative Stress Induces Vascular Calcification through Modulation of the Osteogenic Transcription Factor Runx2 by AKT Signaling

CpG DNA prevents liver injury and shock-mediated death by modulating expression of interleukin-1 receptor-associated kinases.

Inhibition of ZAP-70 Kinase Activity via an Analog-sensitive Allele Blocks T Cell Receptor and CD28 Superagonist $Signaling^{*S⃞}$

Evidence that the Bacillus subtilis SpoIIGA protein is a novel type of signal-transducing aspartic protease.

Combinatorial modification of human histone H4 quantitated by two-dimensional liquid chromatography coupled with top down mass spectrometry.

Appearance and Propagation of Polyglutamine-based Amyloids in Yeast

Permeation Properties of a P2X Receptor in the Green Algae Ostreococcus $tauri^{*}$

Alpha1 soluble guanylyl cyclase (sGC) splice forms as potential regulators of human sGC activity.

Bioluminescence resonance energy transfer assays reveal ligand-specific conformational changes within preformed signaling complexes containing delta-opioid receptors and heterotrimeric G proteins.

X-ray Crystallographic Studies of Substrate Binding to Aristolochene Synthase Suggest a Metal Ion Binding Sequence for Catalysis

Metabolism of the folate precursor p-aminobenzoate in plants: glucose ester formation and vacuolar storage.

The Folding of Human Active and Inactive Extracellular Superoxide Dismutases Is an Intracellular Event

A threonine on the active site loop controls transition state formation in Escherichia coli respiratory complex II.

Peroxisome proliferator-activated receptor-gamma coactivator-1alpha activation of CYP7A1 during food restriction and diabetes is still inhibited by small heterodimer partner.

Dual Specificity Phosphatases 18 and 21 Target to Opposing Sides of the Mitochondrial Inner $Membrane^{*S⃞}$

Assembly of heterohexameric trypanosome hexokinases reveals that hexokinase 2 is a regulable enzyme.

Transforming growth factor beta up-regulates cysteine-rich protein 2 in vascular smooth muscle cells via activating transcription factor 2.

An essential ligand-binding domain in the membrane receptor for retinol-binding protein revealed by large-scale mutagenesis and a human polymorphism.

γ-Aminobutyric Acid (GABA) and Pentobarbital Induce Different Conformational Rearrangements in the $GABA_{A}$ Receptor $α_{1}$ and $β_{2}$ Pre-M1 Regions

Differential Modulation of Akt/Glycogen Synthase Kinase-3β Pathway Regulates Apoptotic and Cytoprotective Signaling Responses

The hyaluronan receptor for endocytosis mediates hyaluronan-dependent signal transduction via extracellular signal-regulated kinases.

Biphasic regulation of HMG-CoA reductase expression and activity during wound healing and its functional role in the control of keratinocyte angiogenic and proliferative responses.

Partial rescue of the amelogenin null dental enamel phenotype.

Deciphering the genetic bases of the structural diversity of phenolic glycolipids in strains of the Mycobacterium tuberculosis complex.

Functional characterization of three G protein-coupled receptors for pigment dispersing factors in Caenorhabditis elegans.

Signaling Properties of a Non-metazoan Src Kinase and the Evolutionary History of Src Negative Regulation

Proton Conductivity through the Human TRPM7 Channel and Its Molecular Determinants

Identification of a novel chondroitin hydrolase in Caenorhabditis elegans.

Mapping the functional interaction of Sco1 and Cox2 in cytochrome oxidase biogenesis.

Hydrolysis of Phosphatidylinositol 4,5-Bisphosphate Mediates Calcium-induced Inactivation of TRPV6 Channels

Beta-fructofuranosidase genes of the silkworm, Bombyx mori: insights into enzymatic adaptation of B. mori to toxic alkaloids in mulberry latex.

STAT6 Inhibits TGF-beta1-mediated Foxp3 induction through direct binding to the Foxp3 promoter, which is reverted by retinoic acid receptor.

Interactions between the Yeast SM22 Homologue Scp1 and Actin Demonstrate the Importance of Actin Bundling in $Endocytosis^{*S⃞}$

ASAP3 is a focal adhesion-associated Arf GAP that functions in cell migration and invasion.

Crystal structures of the 70-kDa heat shock proteins in domain disjoining conformation.

Growth factor-induced phosphorylation of sterol regulatory element-binding proteins inhibits sumoylation, thereby stimulating the expression of their target genes, low density lipoprotein uptake, and lipid synthesis.

The Caenorhabditis elegans AMP-activated protein kinase AAK-2 is phosphorylated by LKB1 and is required for resistance to oxidative stress and for normal motility and foraging behavior.

The miR-200 family inhibits epithelial-mesenchymal transition and cancer cell migration by direct targeting of E-cadherin transcriptional repressors ZEB1 and ZEB2.

Year: 2008 Volume: 283 Issue: 21

Year: 2008 Volume: 283 Issue: 20

Year: 2008 Volume: 283 Issue: 19

Year: 2008 Volume: 283 Issue: 18

Year: 2008 Volume: 283 Issue: 17

Year: 2008 Volume: 283 Issue: 16

Year: 2008 Volume: 283 Issue: 15

Year: 2008 Volume: 283 Issue: 14

Year: 2008 Volume: 283 Issue: 13

Year: 2008 Volume: 283 Issue: 12

Year: 2008 Volume: 283 Issue: 11

Year: 2008 Volume: 283 Issue: 10

Year: 2008 Volume: 283 Issue: 9

Year: 2008 Volume: 283 Issue: 8

Year: 2008 Volume: 283 Issue: 7

Year: 2008 Volume: 283 Issue: 6

Year: 2008 Volume: 283 Issue: 5

Year: 2008 Volume: 283 Issue: 4

Year: 2008 Volume: 283 Issue: 3

Year: 2008 Volume: 283 Issue: 2

Year: 2008 Volume: 283 Issue: 1

Year: 2007 Volume: 282

Year: 2006 Volume: 281

Year: 2005 Volume: 280

Year: 2004 Volume: 279

Year: 2003 Volume: 278

Year: 2002 Volume: 277

Year: 2001 Volume: 276

Year: 2000 Volume: 275

Year: 1999 Volume: 274

Year: 1998 Volume: 273

Year: 1997 Volume: 272

Year: 1996 Volume: 271

Year: 1995 Volume: 270

Year: 1994 Volume: 269

Year: 1993 Volume: 268

Year: 1992 Volume: 267

Year: 1991 Volume: 266

Year: 1990 Volume: 265

Year: 1989 Volume: 264

Year: 1988 Volume: 263

Year: 1987 Volume: 262

Year: 1986 Volume: 261

Year: 1984 Volume: 259

Year: 1982 Volume: 257

Year: 1981 Volume: 256

Year: 1975 Volume: 250

An essential ligand-binding domain in the membrane receptor for retinol-binding protein revealed by large-scale mutagenesis and a human polymorphism.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Yu, Jiamei Honda, Jane Wiita, Patrick Kawaguchi, Riki Sun, Hui
Description	Author Affiliation: Kawaguchi R ( Department of Physiology, Jules Stein Eye Institute, David Geffen School of Medicine at UCLA, University of California-Los Angeles, 650 Charles E. Young Drive, Los Angeles, CA 90095, USA.)
Abstract	Plasma retinol-binding protein (RBP), the principal carrier of vitamin A in the blood, delivers vitamin A from liver, the site of storage, to distant organs that need vitamin A, such as the eye, brain, placenta, and testis. STRA6 is a high-affinity membrane receptor for RBP and mediates vitamin A uptake in these target organs. STRA6 is a 74-kDa multi-transmembrane domain protein that represents a new class of membrane transport protein. In this study, we used an unbiased strategy by analyzing >900 random mutants of STRA6 to study its structure and function, and we identified an essential RBP-binding domain in STRA6. Mutations in any of the three essential residues in this domain can almost completely abolish binding of STRA6 to RBP and its vitamin A uptake activity from holo-RBP without affecting its cell surface expression. We have also functionally characterized the mutations in human STRA6 that cause severe birth defects as well as several human polymorphisms. All STRA6 mutants associated with severe birth defects have largely abolished vitamin A uptake activity, consistent with the severe clinical phenotypes. In addition, we have identified a human polymorphism that significantly reduces the vitamin A uptake activity of STRA6. Interestingly, the residue affected by this polymorphism is located in the RBP-binding domain we identified, and the polymorphism causes decreased vitamin A uptake by reducing RBP binding. This study identifies an essential functional domain in STRA6 and a human polymorphism in this domain that leads to reduced vitamin A uptake activity.
ISSN	00219258
e-ISSN	1083351X
Journal	Journal of Biological Chemistry
Issue Number	22
Volume Number	283
Language	English
Publisher	American Society for Biochemistry and Molecular Biology (United States)
Publisher Date	2008-05-30
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Membrane Proteins Metabolism Mutation Polymorphism, Genetic Retinol-Binding Proteins, Plasma Vitamin A Animals Cell Line Congenital Abnormalities Genetics Mutagenesis Organ Specificity Protein Binding Protein Structure, Tertiary Structure-Activity Relationship Research Support, N.I.H., Extramural Biochemistry Molecular Biology
Content Type	Text
Resource Type	Article
Subject	Cell Biology Biochemistry Molecular Biology

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in