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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Willment, Janet A. Dennehy, Kevin M. Brown, Gordon D. Huysamen, Cristal |
| Description | Author Affiliation: Huysamen C ( Division of Immunology, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, 7925, South Africa.) |
| Abstract | We describe here the first characterization of CLEC9A, a group V C-type lectin-like receptor located in the “Dectin-1 cluster” of related receptors, which are encoded within the natural killer (NK)-gene complex. Expression of human CLEC9A is highly restricted in peripheral blood, being detected only on $BDCA3^{+}$ dendritic cells and on a small subset of $CD14^{+}CD16^{-}$ monocytes. CLEC9A is expressed at the cell surface as a glycosylated dimer and can mediate endocytosis, but not phagocytosis. CLEC9A possesses a cytoplasmic immunoreceptor tyrosine-based activation-like motif that can recruit Syk kinase, and we demonstrate, using receptor chimeras, that this receptor can induce proinflammatory cytokine production. These data indicate that CLEC9A functions as an activation receptor. |
| ISSN | 00219258 |
| e-ISSN | 1083351X |
| Journal | Journal of Biological Chemistry |
| Issue Number | 24 |
| Volume Number | 283 |
| Language | English |
| Publisher | American Society for Biochemistry and Molecular Biology (United States) |
| Publisher Date | 2008-06-13 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Dendritic Cells Cytology Monocytes Receptors, Mitogen Metabolism Amino Acid Motifs Amino Acid Sequence Animals Antigens, CD14 Biosynthesis Endocytosis Intracellular Signaling Peptides And Proteins Lectins, C-Type Mice Models, Biological Molecular Sequence Data Protein-Tyrosine Kinases Receptors, IgG Chemistry Physiology Research Support, Non-U.S. Gov't Biochemistry Molecular Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Biochemistry Molecular Biology |
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