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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Beyer, Sophie Jensen, Kim Steen Johansen, Jens Vilstrup Staller, Peter Kristensen, Malene Maag |
| Description | Author Affiliation: Beyer S ( Biotech Research and Innovation Centre, University of Copenhagen, Copenhagen, Denmark.) |
| Abstract | Posttranslational histone modifications serve to store epigenetic information and control both nucleosome assembly and recruitment of non-histone proteins. Histone methylation occurs on arginine and lysine residues and is involved in the regulation of gene transcription. A dynamic control of these modifications is exerted by histone methyltransferases and the recently discovered histone demethylases. Here we show that the hypoxia-inducible factor HIF-1alpha binds to specific recognition sites in the genes encoding the jumonji family histone demethylases JMJD1A and JMJD2B and induces their expression. Accordingly, hypoxic cells express elevated levels of JMJD1A and JMJD2B mRNA and protein. Furthermore, we find increased expression of JMJD1A and JMJD2B in renal cancer cells that have lost the von Hippel Lindau tumor suppressor protein VHL and therefore display a deregulated expression of hypoxia-inducible factor. Studies on ectopically expressed JMJD1A and JMJD2B indicate that both proteins retain their histone lysine demethylase activity in hypoxia and thereby might impact the hypoxic gene expression program. |
| ISSN | 00219258 |
| e-ISSN | 1083351X |
| Journal | Journal of Biological Chemistry |
| Issue Number | 52 |
| Volume Number | 283 |
| Language | English |
| Publisher | American Society for Biochemistry and Molecular Biology (United States) |
| Publisher Date | 2008-12-26 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Gene Expression Regulation Hypoxia-Inducible Factor 1 Metabolism Oxidoreductases, N-Demethylating Physiology Transcription Factors Arginine Chemistry HeLa Cells Histone Deacetylases Histones Anoxia Jumonji Domain-Containing Histone Demethylases Kidney Embryology Lysine Microscopy, Fluorescence Molecular Sequence Data Biochemistry Molecular Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Biochemistry Molecular Biology |
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