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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Zha, Xiang-ming Hell, Johannes W. Wemmie, John A. Welsh, Michael J. Schnizler, Mikael K. Schnizler, Katrin Hall, Duane D. |
| Description | Author Affiliation: Schnizler MK ( Howard Hughes Medical Institute and Department of Internal Medicine, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.) |
| Abstract | The acid-sensing ion channel 1a (ASIC1a) is widely expressed in central and peripheral neurons where it generates transient cation currents when extracellular pH falls. ASIC1a confers pH-dependent modulation on postsynaptic dendritic spines and has critical effects in neurological diseases associated with a reduced pH. However, knowledge of the proteins that interact with ASIC1a and influence its function is limited. Here, we show that α-actinin, which links membrane proteins to the actin cytoskeleton, associates with ASIC1a in brain and in cultured cells. The interaction depended on an α-actinin-binding site in the ASIC1a C terminus that was specific for ASIC1a versus other ASICs and for α-actinin-1 and -4. Co-expressing α-actinin-4 altered ASIC1a current density, pH sensitivity, desensitization rate, and recovery from desensitization. Moreover, reducing α-actinin expression altered acid-activated currents in hippocampal neurons. These findings suggest that α-actinins may link ASIC1a to a macromolecular complex in the postsynaptic membrane where it regulates ASIC1a activity. |
| ISSN | 00219258 |
| e-ISSN | 1083351X |
| Journal | Journal of Biological Chemistry |
| Issue Number | 5 |
| Volume Number | 284 |
| Language | English |
| Publisher | American Society for Biochemistry and Molecular Biology (United States) |
| Publisher Date | 2009-01-30 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Actinin Metabolism Physiology Nerve Tissue Proteins Sodium Channels Acid Sensing Ion Channels Animals Binding Sites Brain CHO Cells Cricetinae Cricetulus DNA Primers Mice Chemistry Patch-Clamp Techniques RNA Interference Reverse Transcriptase Polymerase Chain Reaction Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Biochemistry Molecular Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Biochemistry Molecular Biology |
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