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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Ikegami, Machiko Postle, Anthony D. Xu, Yan Wert, Susan E. Whitsett, Jeffrey A. Besnard, Valérie Stahlman, Mildred T. |
| Description | Author Affiliation: Besnard V ( Division of Pulmonary Biology, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, the University of Cincinnati College of Medicine, Cincinnati, Ohio 45229-3039, USA.) |
| Abstract | Pulmonary function after birth is dependent upon surfactant lipids that reduce surface tension in the alveoli. The sterol-responsive element-binding proteins (SREBPs) are transcription factors regulating expression of genes controlling lipid homeostasis in many tissues. To identify the role of SREBPs in the lung, we conditionally deleted the SREBP cleavage-activating protein gene, Scap, in respiratory epithelial cells (ScapDelta/Delta) in vivo. Prior to birth (E18.5), deletion of Scap decreased the expression of both SREBPs and a number of genes regulating fatty acid and cholesterol metabolism. Nevertheless, ScapDelta/Delta mice survived postnatally, surfactant and lung tissue lipids being substantially normalized in adult ScapDelta/Delta mice. Although phospholipid synthesis was decreased in type II cells from adult ScapDelta/Delta mice, lipid storage, synthesis, and transfer by lung lipofibroblasts were increased. mRNA microarray data indicated that SCAP influenced two major gene networks, one regulating lipid metabolism and the other stress-related responses. Deletion of the SCAP/SREBP pathway in respiratory epithelial cells altered lung lipid homeostasis and induced compensatory lipid accumulation and synthesis in lung lipofibroblasts. |
| ISSN | 00219258 |
| e-ISSN | 1083351X |
| Journal | Journal of Biological Chemistry |
| Issue Number | 6 |
| Volume Number | 284 |
| Language | English |
| Publisher | American Society for Biochemistry and Molecular Biology (United States) |
| Publisher Date | 2009-02-06 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Fibroblasts Metabolism Homeostasis Physiology Intracellular Signaling Peptides And Proteins Lipid Metabolism Membrane Proteins Pulmonary Alveoli Animals Cytology Gene Deletion Gene Expression Regulation Genetics Mice Mice, Transgenic Phospholipids Sterol Regulatory Element Binding Proteins Research Support, N.I.H., Extramural Biochemistry Molecular Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Biochemistry Molecular Biology |
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