NDLI: Loss of α-Dystroglycan Laminin Binding in Epithelium-derived Cancers Is Caused by Silencing of $LARGE^{*S⃞♦}$

Please wait, while we are loading the content...

Year: 2017 Volume: 292

Year: 2016 Volume: 291

Year: 2015 Volume: 290

Year: 2014 Volume: 289

Year: 2013 Volume: 288

Year: 2012 Volume: 287

Year: 2011 Volume: 286

Year: 2010 Volume: 285

Year: 2009 Volume: 284

Year: 2009 Volume: 284 Issue: 52

Year: 2009 Volume: 284 Issue: 51

Year: 2009 Volume: 284 Issue: 50

Year: 2009 Volume: 284 Issue: 49

Year: 2009 Volume: 284 Issue: 48

Year: 2009 Volume: 284 Issue: 47

Year: 2009 Volume: 284 Issue: 46

Year: 2009 Volume: 284 Issue: 45

Year: 2009 Volume: 284 Issue: 44

Year: 2009 Volume: 284 Issue: 43

Year: 2009 Volume: 284 Issue: 42

Year: 2009 Volume: 284 Issue: 41

Year: 2009 Volume: 284 Issue: 40

Year: 2009 Volume: 284 Issue: 39

Year: 2009 Volume: 284 Issue: 38

Year: 2009 Volume: 284 Issue: 37

Year: 2009 Volume: 284 Issue: 36

Year: 2009 Volume: 284 Issue: 35

Year: 2009 Volume: 284 Issue: 34

Year: 2009 Volume: 284 Issue: 33

Year: 2009 Volume: 284 Issue: 32

Year: 2009 Volume: 284 Issue: 31

Year: 2009 Volume: 284 Issue: 30

Year: 2009 Volume: 284 Issue: 29

Year: 2009 Volume: 284 Issue: 28

Year: 2009 Volume: 284 Issue: 27

Year: 2009 Volume: 284 Issue: 26

Year: 2009 Volume: 284 Issue: 25

Year: 2009 Volume: 284 Issue: 24

Year: 2009 Volume: 284 Issue: 23

Year: 2009 Volume: 284 Issue: 22

Year: 2009 Volume: 284 Issue: 21

Year: 2009 Volume: 284 Issue: 20

Year: 2009 Volume: 284 Issue: 19

Year: 2009 Volume: 284 Issue: 18

Year: 2009 Volume: 284 Issue: 17

Signaling threshold regulation by the Ras effector IMP.

Rassf family of tumor suppressor polypeptides.

Specificity in Ras and Rap signaling.

Detecting morphologically distinct oligomeric forms of alpha-synuclein.

MEK1 binds directly to betaarrestin1, influencing both its phosphorylation by ERK and the timing of its isoprenaline-stimulated internalization.

Hyaluronan mediates ozone-induced airway hyperresponsiveness in mice.

Structure and function of an NADPH-cytochrome P450 oxidoreductase in an open conformation capable of reducing cytochrome P450.

Structural and Functional Analysis of Transmembrane XI of the NHE1 Isoform of the $Na^{+}/H^{+}$ Exchanger

Streptococcus pneumoniae endohexosaminidase D, structural and mechanistic insight into substrate-assisted catalysis in family 85 glycoside hydrolases.

A Function for the RING Finger Domain in the Allosteric Control of MDM2 Conformation and Activity

T cell receptor-dependent tyrosine phosphorylation of beta2-chimaerin modulates its Rac-GAP function in T cells.

Activation of the Oxidative Stress Pathway by HIV-1 Vpr Leads to Induction of Hypoxia-inducible Factor 1α Expression

Functional characterization of two secreted SEL1L isoforms capable of exporting unassembled substrate.

A central role for decorin during vertebrate convergent extension.

Identification of a post-targeting step required for efficient cotranslational translocation of proteins across the Escherichia coli inner membrane.

Crystal structure of biotin carboxylase in complex with substrates and implications for its catalytic mechanism.

The Toca-1-N-WASP Complex Links Filopodial Formation to Endocytosis

ADAM10, the rate-limiting protease of regulated intramembrane proteolysis of Notch and other proteins, is processed by ADAMS-9, ADAMS-15, and the gamma-secretase.

Importin 13 mediates nuclear import of histone fold-containing chromatin accessibility complex heterodimers.

Shift from apoptotic to necrotic cell death during human papillomavirus-induced transformation of keratinocytes.

Regulation of neuronal cell death by MST1-FOXO1 signaling.

Down-regulation of mitochondrial acyl carrier protein in mammalian cells compromises protein lipoylation and respiratory complex I and results in cell death.

Oligomerization of the macrophage mannose receptor enhances gp120-mediated binding of HIV-1.

Synphilin-1A inhibits seven in absentia homolog (SIAH) and modulates alpha-synuclein monoubiquitylation and inclusion formation.

Essential role of one-carbon metabolism and Gcn4p and Bas1p transcriptional regulators during adaptation to anaerobic growth of Saccharomyces cerevisiae.

Distinct nucleotide binding/hydrolysis properties and molar ratio of MutSalpha and MutSbeta determine their differential mismatch binding activities.

GLEPP1/protein-tyrosine phosphatase phi inhibitors block chemotaxis in vitro and in vivo and improve murine ulcerative colitis.

Cleavage of Bid by executioner caspases mediates feed forward amplification of mitochondrial outer membrane permeabilization during genotoxic stress-induced apoptosis in Jurkat cells.

Septin 11 Restricts InlB-mediated Invasion by $Listeria^{S⃞}$

Hepatoma-derived growth factor-related protein-3 interacts with microtubules and promotes neurite outgrowth in mouse cortical neurons.

FGF15/FGFR4 integrates growth factor signaling with hepatic bile acid metabolism and insulin action.

The fission yeast SEL1 domain protein Cfh3p: a novel regulator of the glucan synthase Bgs1p whose function is more relevant under stress conditions.

Kindlin-1 and -2 directly bind the C-terminal region of beta integrin cytoplasmic tails and exert integrin-specific activation effects.

An alternatively spliced isoform of non-muscle myosin II-C is not regulated by myosin light chain phosphorylation.

Cleavage at Arg-1689 Influences Heavy Chain Cleavages during Thrombin-catalyzed Activation of Factor VIII

SCAMP5 links endoplasmic reticulum stress to the accumulation of expanded polyglutamine protein aggregates via endocytosis inhibition.

SNAT2 amino acid transporter is regulated by amino acids of the SLC6 gamma-aminobutyric acid transporter subfamily in neocortical neurons and may play no role in delivering glutamine for glutamatergic transmission.

Heterogeneous nuclear ribonucleoproteins H and F regulate the proteolipid protein/DM20 ratio by recruiting U1 small nuclear ribonucleoprotein through a complex array of G runs.

Targeted transgenic expression of an osteoclastic transmembrane protein-tyrosine phosphatase in cells of osteoclastic lineage increases bone resorption and bone loss in male young adult mice.

Lens epithelium-derived growth factor/p75 interacts with the transposase-derived DDE domain of PogZ.

Interactions of lipopolysaccharide and polymyxin studied by NMR spectroscopy.

Identification of a Cardiolipin-specific Phospholipase Encoded by the Gene CLD1 (YGR110W) in $Yeast^{*}$

Loss of α-Dystroglycan Laminin Binding in Epithelium-derived Cancers Is Caused by Silencing of $LARGE^{*S⃞♦}$

The Role of the βDELSEED-loop of ATP Synthase

Lysosomal serine protease CLN2 regulates tumor necrosis factor-alpha-mediated apoptosis in a Bid-dependent manner.

The Silkworm Mutant lemon (lemon lethal) Is a Potential Insect Model for Human Sepiapterin Reductase Deficiency

Hydrolase regulates NAD+ metabolites and modulates cellular redox.

Subcellular Origin of Sphingosine 1-Phosphate Is Essential for Its Toxic Effect in Lyase-deficient Neurons

SEPT9_v1 Up-regulates Hypoxia-inducible Factor 1 by Preventing Its RACK1-mediated Degradation

The Mycobacterium tuberculosis protein kinase K modulates activation of transcription from the promoter of mycobacterial monooxygenase operon through phosphorylation of the transcriptional regulator VirS.

SUMO modification regulates the transcriptional repressor function of aryl hydrocarbon receptor repressor.

p38alpha and p38gamma mediate oncogenic ras-induced senescence through differential mechanisms.

miR-199a, a bone morphogenic protein 2-responsive MicroRNA, regulates chondrogenesis via direct targeting to Smad1.

Active site of cytochrome cbb3.

A type III protein arginine methyltransferase from the protozoan parasite Trypanosoma brucei.

Role of $Ca^{2+}/Calmodulin-dependent$ Protein Kinase II in Drosophila Photoreceptors

Defects in transient tRNA translocation bypass tRNA synthetase quality control mechanisms.

Unfractionated heparin and new heparin analogues from ascidians (chordate-tunicate) ameliorate colitis in rats.

Tristetraprolin mediates interferon-gamma mRNA decay.

Identification of MUP1 as a regulator for glucose and lipid metabolism in mice.

Two snapshots of electron transport across the membrane: insights into the structure and function of DsbD.

Formation of two intramolecular disulfide bonds is necessary for ApoA-I-dependent cholesterol efflux mediated by ABCA1.

Curcuminoid biosynthesis by two type III polyketide synthases in the herb Curcuma longa.

Disulfide bond formation significantly accelerates the assembly of Ure2p fibrils because of the proximity of a potential amyloid stretch.

The Cul3/Klhdc5 E3 ligase regulates p60/katanin and is required for normal mitosis in mammalian cells.

$H_{2}S$ Biogenesis by Human Cystathionine γ-Lyase Leads to the Novel Sulfur Metabolites Lanthionine and Homolanthionine and Is Responsive to the Grade of Hyperhomocysteinemia

Residues important for nitrate/proton coupling in plant and mammalian CLC transporters.

Calcitonin, a regulator of the 25-hydroxyvitamin D3 1alpha-hydroxylase gene.

Bortezomib overcomes tumor necrosis factor-related apoptosis-inducing ligand resistance in hepatocellular carcinoma cells in part through the inhibition of the phosphatidylinositol 3-kinase/Akt pathway.

The structural basis for recognition of the PreQ0 metabolite by an unusually small riboswitch aptamer domain.

Polypurine hairpins directed against the template strand of DNA knock down the expression of mammalian genes.

GEF-H1 mediates tumor necrosis factor-alpha-induced Rho activation and myosin phosphorylation: role in the regulation of tubular paracellular permeability.

p53 acetylation is crucial for its transcription-independent proapoptotic functions.

The D816V mutation of c-Kit circumvents a requirement for Src family kinases in c-Kit signal transduction.

Acetylation/deacetylation modulates the stability of DNA replication licensing factor Cdt1.

Year: 2009 Volume: 284 Issue: 16

Year: 2009 Volume: 284 Issue: 15

Year: 2009 Volume: 284 Issue: 14

Year: 2009 Volume: 284 Issue: 13

Year: 2009 Volume: 284 Issue: 12

Year: 2009 Volume: 284 Issue: 11

Year: 2009 Volume: 284 Issue: 10

Year: 2009 Volume: 284 Issue: 9

Year: 2009 Volume: 284 Issue: 8

Year: 2009 Volume: 284 Issue: 7

Year: 2009 Volume: 284 Issue: 6

Year: 2009 Volume: 284 Issue: 5

Year: 2009 Volume: 284 Issue: 4

Year: 2009 Volume: 284 Issue: 3

Year: 2009 Volume: 284 Issue: 2

Year: 2009 Volume: 284 Issue: 1

Year: 2008 Volume: 283

Year: 2007 Volume: 282

Year: 2006 Volume: 281

Year: 2005 Volume: 280

Year: 2004 Volume: 279

Year: 2003 Volume: 278

Year: 2002 Volume: 277

Year: 2001 Volume: 276

Year: 2000 Volume: 275

Year: 1999 Volume: 274

Year: 1998 Volume: 273

Year: 1997 Volume: 272

Year: 1996 Volume: 271

Year: 1995 Volume: 270

Year: 1994 Volume: 269

Year: 1993 Volume: 268

Year: 1992 Volume: 267

Year: 1991 Volume: 266

Year: 1990 Volume: 265

Year: 1989 Volume: 264

Year: 1988 Volume: 263

Year: 1987 Volume: 262

Year: 1986 Volume: 261

Year: 1984 Volume: 259

Year: 1982 Volume: 257

Year: 1981 Volume: 256

Year: 1975 Volume: 250

Loss of α-Dystroglycan Laminin Binding in Epithelium-derived Cancers Is Caused by Silencing of $LARGE^{*S⃞♦}$

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Yoshida-moriguchi, Takako De Bernabé, Daniel Beltrán-valero Harper, Hollie A. Inamori, Kei-ichiro Henry, Michael D. Campbell, Kevin P. Weydert, Christine J. Willer, Tobias
Description	Author Affiliation: de Bernabé DB ( Howard Hughes Medical Institute, University of Iowa, Roy J. and Lucille A. Carver College of Medicine, Iowa City, Iowa 52242-1101, USA.)
Abstract	The interaction between epithelial cells and the extracellular matrix is crucial for tissue architecture and function and is compromised during cancer progression. Dystroglycan is a membrane receptor that mediates interactions between cells and basement membranes in various epithelia. In many epithelium-derived cancers, β-dystroglycan is expressed, but α-dystroglycan is not detected. Here we report that α-dystroglycan is correctly expressed and trafficked to the cell membrane but lacks laminin binding as a result of the silencing of the like-acetylglucosaminyltransferase (LARGE) gene in a cohort of highly metastatic epithelial cell lines derived from breast, cervical, and lung cancers. Exogenous expression of LARGE in these cancer cells restores the normal glycosylation and laminin binding of α-dystroglycan, leading to enhanced cell adhesion and reduced cell migration in vitro. Our findings demonstrate that LARGE repression is responsible for the defects in dystroglycan-mediated cell adhesion that are observed in epithelium-derived cancer cells and point to a defect of dystroglycan glycosylation as a factor in cancer progression.
ISSN	00219258
e-ISSN	1083351X
Journal	Journal of Biological Chemistry
Issue Number	17
Volume Number	284
Language	English
Publisher	American Society for Biochemistry and Molecular Biology (United States)
Publisher Date	2009-04-24
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Dystroglycans Metabolism Epithelium Pathology Gene Expression Regulation, Neoplastic Laminin N-Acetylglucosaminyltransferases Skin Neoplasms Cell Adhesion Cell Line, Tumor Gene Silencing Glycosylation HeLa Cells Models, Biological Neoplasm Metastasis Protein Binding Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Biochemistry Molecular Biology
Content Type	Text
Resource Type	Article
Subject	Cell Biology Biochemistry Molecular Biology

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in