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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Hehl, Adrian B. Pieters, Jean Stefanic, Sasa Schraner, Elisabeth Bottova, Iveta Casas, Josefina Fabriàs, Gemma Sonda, Sabrina |
| Description | Author Affiliation: Bottova I ( Institute of Parasitology, University of Zurich, Zurich, Switzerland.) |
| Abstract | P-glycoprotein (P-gp) is a membrane-bound efflux pump that actively exports a wide range of compounds from the cell and is associated with the phenomenon of multidrug resistance. However, the role of P-gp in normal physiological processes remains elusive. Using P-gp-deficient fibroblasts, we showed that P-gp was critical for the replication of the intracellular parasite Toxoplasma gondii but was not involved in invasion of host cells by the parasite. Importantly, we found that the protein participated in the transport of host-derived cholesterol to the intracellular parasite. T. gondii replication in P-gp-deficient host cells not only resulted in reduced cholesterol content in the parasite but also altered its sphingolipid metabolism. In addition, we found that different levels of P-gp expression modified the cholesterol metabolism in uninfected fibroblasts. Collectively our findings reveal a key and previously undocumented role of P-gp in host-parasite interaction and suggest a physiological role for P-gp in cholesterol trafficking in mammalian cells. |
| ISSN | 00219258 |
| e-ISSN | 1083351X |
| Journal | Journal of Biological Chemistry |
| Issue Number | 26 |
| Volume Number | 284 |
| Language | English |
| Publisher | American Society for Biochemistry and Molecular Biology (United States) |
| Publisher Date | 2009-06-26 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Cholesterol Metabolism P-Glycoproteins Physiology Toxoplasma Growth & Development Animals Biological Transport Blotting, Western Cells, Cultured Chromatography, Liquid Embryo, Mammalian Cytology Fibroblasts Fluorescent Antibody Technique Host-Parasite Interactions Lipids Mass Spectrometry Mice Mice, Knockout NIH 3T3 Cells Parasitology Neospora Research Support, Non-U.S. Gov't Biochemistry Molecular Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Biochemistry Molecular Biology |
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