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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Powlesland, Alex S. Taylor, Maureen E. Yan, Sheng Brady, Jacob P. Jégouzo, Sabine A. F. Graham, Sarah A. Drickamer, Kurt |
| Description | Author Affiliation: Graham SA ( Division of Molecular Biosciences, Department of Life Sciences, Imperial College, London SW7 2AZ, United Kingdom.) |
| Abstract | Prolectin, a previously undescribed glycan-binding receptor, has been identified by re-screening of the human genome for genes encoding proteins containing potential C-type carbohydrate-recognition domains. Glycan array analysis revealed that the carbohydrate-recognition domain in the extracellular domain of the receptor binds glycans with terminal α-linked mannose or fucose residues. Prolectin expressed in fibroblasts is found at the cell surface, but unlike many glycan-binding receptors it does not mediate endocytosis of a neoglycoprotein ligand. However, compared with other known glycan-binding receptors, the receptor contains an unusually large intracellular domain that consists of multiple sequence motifs, including phosphorylated tyrosine residues, that allow it to interact with signaling molecules such as Grb2. Immunohistochemistry has been used to demonstrate that prolectin is expressed on a specialized population of proliferating B cells in germinal centers. Thus, this novel receptor has the potential to function in carbohydrate-mediated communication between cells in the germinal center. |
| ISSN | 00219258 |
| e-ISSN | 1083351X |
| Journal | Journal of Biological Chemistry |
| Issue Number | 27 |
| Volume Number | 284 |
| Language | English |
| Publisher | American Society for Biochemistry and Molecular Biology (United States) |
| Publisher Date | 2009-07-03 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | B-Lymphocytes Physiology Germinal Center Lectins, C-Type Chemistry Genetics Polysaccharides Metabolism Receptors, Cell Surface Amino Acid Sequence Animals Antibodies Pharmacology Binding, Competitive Cell Communication Cell Division Cytoplasm Extracellular Space Fibroblasts Cytology Immunohistochemistry Molecular Sequence Data Protein Structure, Tertiary Protein Transport Rabbits Signal Transduction Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Biochemistry Molecular Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Biochemistry Molecular Biology |
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