NDLI: Androgen via p21 inhibits tumor necrosis factor alpha-induced JNK activation and apoptosis.

Please wait, while we are loading the content...

Year: 2017 Volume: 292

Year: 2016 Volume: 291

Year: 2015 Volume: 290

Year: 2014 Volume: 289

Year: 2013 Volume: 288

Year: 2012 Volume: 287

Year: 2011 Volume: 286

Year: 2010 Volume: 285

Year: 2009 Volume: 284

Year: 2009 Volume: 284 Issue: 52

Year: 2009 Volume: 284 Issue: 51

Year: 2009 Volume: 284 Issue: 50

Year: 2009 Volume: 284 Issue: 49

Year: 2009 Volume: 284 Issue: 48

Year: 2009 Volume: 284 Issue: 47

Agonist dose-dependent phosphorylation by protein kinase A and G protein-coupled receptor kinase regulates beta2 adrenoceptor coupling to G(i) proteins in cardiomyocytes.

T cell receptor signaling co-regulates multiple Golgi genes to enhance N-glycan branching.

Two lysine residues in the bacterial luciferase mobile loop stabilize reaction intermediates.

A bifunctional intronic element regulates the expression of the arginine/lysine transporter Cat-1 via mechanisms involving the purine-rich element binding protein A (Pur alpha).

Androgen via p21 inhibits tumor necrosis factor alpha-induced JNK activation and apoptosis.

Mechanistic Details of Glutathione Biosynthesis Revealed by Crystal Structures of Saccharomyces cerevisiae Glutamate Cysteine Ligase

The Kruppel-like zinc finger protein ZNF224 recruits the arginine methyltransferase PRMT5 on the transcriptional repressor complex of the aldolase A gene.

A Sporadic Parkinson Disease Model via Silencing of the Ubiquitin-Proteasome/E3 Ligase Component SKP1A

The mammalian Hsp40 ERdj3 requires its Hsp70 interaction and substrate-binding properties to complement various yeast Hsp40-dependent functions.

Docosahexaenoic acid enhances hepatic serum amyloid A expression via protein kinase A-dependent mechanism.

Different strategies adopted by K(b) and L(d) to generate T cell specificity directed against their respective bound peptides.

Elevation of glutamine level by selenophosphate synthetase 1 knockdown induces megamitochondrial formation in Drosophila cells.

Transition States.

Crystal structure of a mucus-binding protein repeat reveals an unexpected functional immunoglobulin binding activity.

Isolation and characterization of patient-derived, toxic, high mass amyloid beta-protein (Abeta) assembly from Alzheimer disease brains.

Electrophilic affibodies forming covalent bonds to protein targets.

The dexamethasone-induced inhibition of proliferation, migration, and invasion in glioma cell lines is antagonized by macrophage migration inhibitory factor (MIF) and can be enhanced by specific MIF inhibitors.

Bax1 is a novel endonuclease: implications for archaeal nucleotide excision repair.

Structure and interdomain dynamics of apoptosis-associated speck-like protein containing a CARD (ASC).

Naturally Occurring Mutations Alter the Stability of Polycystin-1 Polycystic Kidney Disease (PKD) $Domains^{*}$

CK1α Plays a Central Role in Mediating MDM2 Control of p53 and E2F-1 Protein Stability

SAGA and Rpd3 Chromatin Modification Complexes Dynamically Regulate Heat Shock Gene Structure and Expression

The ATPase cycle of the mitotic motor CENP-E.

A distributed set of interactions controls mu2 functionality in the role of AP-2 as a sorting adaptor in synaptic vesicle endocytosis.

Polypyrimidine tract binding protein prevents activity of an intronic regulatory element that promotes usage of a composite 3'-terminal exon.

Asparagine-linked Oligosaccharides Present on a Non-consensus Amino Acid Sequence in the $C_{H}1$ Domain of Human Antibodies

Complex Phosphatase Regulation of $Ca^{2+}-activated$ $Cl^{−}$ Currents in Pulmonary Arterial Smooth Muscle Cells

Molecular basis for zinc transporter 1 action as an endogenous inhibitor of L-type calcium channels.

Alternative mRNA splicing produces a novel biologically active short isoform of PGC-1alpha.

C-terminal domains of transmembrane alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptor regulatory proteins not only facilitate trafficking but are major modulators of AMPA receptor function.

Galectin-9 is a high affinity IgE-binding lectin with anti-allergic effect by blocking IgE-antigen complex formation.

Control of Respiration by Cytochrome c Oxidase in Intact Cells: ROLE OF THE MEMBRANE POTENTIAL

Phosphorylation of Williams syndrome transcription factor by MAPK induces a switching between two distinct chromatin remodeling complexes.

Direct modification of the proinflammatory cytokine macrophage migration inhibitory factor by dietary isothiocyanates.

Interleukin-10 facilitates both cholesterol uptake and efflux in macrophages.

Interactions between EB1 and microtubules: dramatic effect of affinity tags and evidence for cooperative behavior.

JNK and Ceramide Kinase Govern the Biogenesis of Lipid Droplets through Activation of Group IVA Phospholipase $A_{2}$

Localization, purification, and functional reconstitution of the P4-ATPase Atp8a2, a phosphatidylserine flippase in photoreceptor disc membranes.

Blocking L-type Voltage-gated $Ca^{2+}$ Channels with Dihydropyridines Reduces γ-Aminobutyric Acid Type A Receptor Expression and Synaptic Inhibition

The Endoplasmic Reticulum of Dorsal Root Ganglion Neurons Contains Functional TRPV1 Channels

Preferred sequences within a defined cleavage window specify DNA 3' end-directed cleavages by retroviral RNases H.

Depletion of selenoprotein GPx4 in spermatocytes causes male infertility in mice.

The macrophage cholesterol exporter ABCA1 functions as an anti-inflammatory receptor.

Differential involvement of Atg16L1 in Crohn disease and canonical autophagy: analysis of the organization of the Atg16L1 complex in fibroblasts.

Involvement of the β Clamp in Methyl-directed Mismatch Repair in $Vitro^{*}$

Discovery and investigation of misincorporation of serine at asparagine positions in recombinant proteins expressed in Chinese hamster ovary cells.

GCN2 protein kinase is required to activate amino acid deprivation responses in mice treated with the anti-cancer agent L-asparaginase.

Membrane rafts are involved in intracellular miconazole accumulation in yeast cells.

PGRL1 participates in iron-induced remodeling of the photosynthetic apparatus and in energy metabolism in Chlamydomonas reinhardtii.

ScFv antibody-induced translocation of cell-surface heparan sulfate proteoglycan to endocytic vesicles: evidence for heparan sulfate epitope specificity and role of both syndecan and glypican.

ADP signaling in vascular endothelial cells: ADP-dependent activation of the endothelial isoform of nitric-oxide synthase requires the expression but not the kinase activity of AMP-activated protein kinase.

Myocardin-dependent activation of the CArG box-rich smooth muscle gamma-actin gene: preferential utilization of a single CArG element through functional association with the NKX3.1 homeodomain protein.

Tight coupling between glucose and mitochondrial metabolism in clonal beta-cells is required for robust insulin secretion.

D-AKAP2 Interacts with Rab4 and Rab11 through Its RGS Domains and Regulates Transferrin Receptor $Recycling^{*}$

Identification and characterization of propionylation at histone H3 lysine 23 in mammalian cells.

Inhibition of the Equilibrative Nucleoside Transporter 1 and Activation of $A_{2A}$ Adenosine Receptors by 8-(4-Chlorophenylthio)-modified cAMP Analogs and Their Hydrolytic Products

Phosphorylation of neuronal survival factor MEF2D by glycogen synthase kinase 3beta in neuronal apoptosis.

Heparan sulfate and transglutaminase activity are required for the formation of covalently cross-linked hedgehog oligomers.

Characterization of human cone phosphodiesterase-6 ectopically expressed in Xenopus laevis rods.

Yeast colony survival depends on metabolic adaptation and cell differentiation rather than on stress defense.

Three-way interaction between 14-3-3 proteins, the N-terminal region of tyrosine hydroxylase, and negatively charged membranes.

Complex regulation of tartrate-resistant acid phosphatase (TRAP) expression by interleukin 4 (IL-4): IL-4 indirectly suppresses receptor activator of NF-kappaB ligand (RANKL)-mediated TRAP expression but modestly induces its expression directly.

Mixed lineage kinase phosphorylates transcription factor E47 and inhibits TrkB expression to link neuronal death and survival pathways.

Roles of Two $Ca^{2+}-binding$ Domains in Regulation of the Cardiac $Na^{+}-Ca^{2+}$ Exchanger

Von Hippel-Lindau gene product modulates TIS11B expression in renal cell carcinoma: impact on vascular endothelial growth factor expression in hypoxia.

Saccharomyces CDK1 phosphorylates Rad53 kinase in metaphase, influencing cellular morphogenesis.

A mycobacterial cyclic AMP phosphodiesterase that moonlights as a modifier of cell wall permeability.

Crystal structure and catalytic mechanism of 4-methylmuconolactone methylisomerase.

Thymidine analogue resistance suppression by V75I of HIV-1 reverse transcriptase: effects of substituting valine 75 on stavudine excision and discrimination.

Identification of residues in the 558-loop of factor VIIIa A2 subunit that interact with factor IXa.

Identification and functional characterization of ERK/MAPK phosphorylation sites in the Runx2 transcription factor.

Role of spike protein endodomains in regulating coronavirus entry.

Phosphoglucose isomerase/autocrine motility factor promotes melanoma cell migration through ERK activation dependent on autocrine production of interleukin-8.

A novel role for hGas7b in microtubular maintenance: possible implication in tau-associated pathology in Alzheimer disease.

Identification of a new exosite involved in catalytic turnover by the streptokinase-plasmin activator complex during human plasminogen activation.

A new model for the transition of APAF-1 from inactive monomer to caspase-activating apoptosome.

Transcriptional regulation of mouse mast cell protease-2 by interleukin-15.

Proteomics reveals a physical and functional link between hepatocyte nuclear factor 4alpha and transcription factor IID.

A promiscuous conformational switch in the secondary multidrug transporter MdfA.

Domain II loop 3 of Bacillus thuringiensis Cry1Ab toxin is involved in a 'ping pong' binding mechanism with Manduca sexta aminopeptidase-N and cadherin receptors.

Phosphatase and tensin homologue on chromosome 10 (PTEN) directs prostaglandin E2-mediated fibroblast responses via regulation of E prostanoid 2 receptor expression.

Year: 2009 Volume: 284 Issue: 46

Year: 2009 Volume: 284 Issue: 45

Year: 2009 Volume: 284 Issue: 44

Year: 2009 Volume: 284 Issue: 43

Year: 2009 Volume: 284 Issue: 42

Year: 2009 Volume: 284 Issue: 41

Year: 2009 Volume: 284 Issue: 40

Year: 2009 Volume: 284 Issue: 39

Year: 2009 Volume: 284 Issue: 38

Year: 2009 Volume: 284 Issue: 37

Year: 2009 Volume: 284 Issue: 36

Year: 2009 Volume: 284 Issue: 35

Year: 2009 Volume: 284 Issue: 34

Year: 2009 Volume: 284 Issue: 33

Year: 2009 Volume: 284 Issue: 32

Year: 2009 Volume: 284 Issue: 31

Year: 2009 Volume: 284 Issue: 30

Year: 2009 Volume: 284 Issue: 29

Year: 2009 Volume: 284 Issue: 28

Year: 2009 Volume: 284 Issue: 27

Year: 2009 Volume: 284 Issue: 26

Year: 2009 Volume: 284 Issue: 25

Year: 2009 Volume: 284 Issue: 24

Year: 2009 Volume: 284 Issue: 23

Year: 2009 Volume: 284 Issue: 22

Year: 2009 Volume: 284 Issue: 21

Year: 2009 Volume: 284 Issue: 20

Year: 2009 Volume: 284 Issue: 19

Year: 2009 Volume: 284 Issue: 18

Year: 2009 Volume: 284 Issue: 17

Year: 2009 Volume: 284 Issue: 16

Year: 2009 Volume: 284 Issue: 15

Year: 2009 Volume: 284 Issue: 14

Year: 2009 Volume: 284 Issue: 13

Year: 2009 Volume: 284 Issue: 12

Year: 2009 Volume: 284 Issue: 11

Year: 2009 Volume: 284 Issue: 10

Year: 2009 Volume: 284 Issue: 9

Year: 2009 Volume: 284 Issue: 8

Year: 2009 Volume: 284 Issue: 7

Year: 2009 Volume: 284 Issue: 6

Year: 2009 Volume: 284 Issue: 5

Year: 2009 Volume: 284 Issue: 4

Year: 2009 Volume: 284 Issue: 3

Year: 2009 Volume: 284 Issue: 2

Year: 2009 Volume: 284 Issue: 1

Year: 2008 Volume: 283

Year: 2007 Volume: 282

Year: 2006 Volume: 281

Year: 2005 Volume: 280

Year: 2004 Volume: 279

Year: 2003 Volume: 278

Year: 2002 Volume: 277

Year: 2001 Volume: 276

Year: 2000 Volume: 275

Year: 1999 Volume: 274

Year: 1998 Volume: 273

Year: 1997 Volume: 272

Year: 1996 Volume: 271

Year: 1995 Volume: 270

Year: 1994 Volume: 269

Year: 1993 Volume: 268

Year: 1992 Volume: 267

Year: 1991 Volume: 266

Year: 1990 Volume: 265

Year: 1989 Volume: 264

Year: 1988 Volume: 263

Year: 1987 Volume: 262

Year: 1986 Volume: 261

Year: 1984 Volume: 259

Year: 1982 Volume: 257

Year: 1981 Volume: 256

Year: 1975 Volume: 250

Androgen via p21 inhibits tumor necrosis factor alpha-induced JNK activation and apoptosis.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Kokontis, John Lin, Yuting Liao, Shutsung Xiang, Jialing Lin, Anning Tang, Fangming
Description	Author Affiliation: Tang F ( Ben May Department for Cancer Research, University of Chicago, Chicago, Illinois 60637, USA.)
Abstract	The male hormone androgen is a growth/survival factor for its target tissues or organs. Yet, the underlying mechanism is incompletely understood. Here, we report that androgen via p21 inhibits tumor necrosis factor alpha-induced JNK activation and apoptosis. Inhibition by androgen requires the transcription activity of androgen receptor (AR) and de novo protein synthesis. Androgen.AR induces expression of p21 that in turn inhibits tumor necrosis factor alpha-induced JNK and apoptosis. Furthermore, genetic interruption of p21 alleles abolishes the inhibition by androgen. Our results reveal a novel cross-talk between androgen x AR and JNK, thereby providing a molecular mechanism underlying the survival function of androgen.
ISSN	00219258
e-ISSN	1083351X
Journal	Journal of Biological Chemistry
Issue Number	47
Volume Number	284
Language	English
Publisher	American Society for Biochemistry and Molecular Biology (United States)
Publisher Date	2009-11-20
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Androgens Metabolism Cyclin-Dependent Kinase Inhibitor P21 Gene Expression Regulation, Neoplastic MAP Kinase Kinase 4 Tumor Necrosis Factor-alpha Alleles Apoptosis Cell Line, Tumor Enzyme Activation Models, Biological Prostatic Neoplasms Receptors, Androgen Transcription, Genetic Research Support, N.I.H., Extramural Biochemistry Molecular Biology
Content Type	Text
Resource Type	Article
Subject	Cell Biology Biochemistry Molecular Biology

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in