NDLI: An RNA recognition motif mediates the nucleocytoplasmic transport of a trypanosome RNA-binding protein.

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An RNA recognition motif mediates the nucleocytoplasmic transport of a trypanosome RNA-binding protein.

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An RNA recognition motif mediates the nucleocytoplasmic transport of a trypanosome RNA-binding protein.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Cassola, Alejandro Frasch, Alberto C.
Description	Author Affiliation: Cassola A ( Instituto de Investigaciones Biotecnológicas-Instituto Tecnológico Chascomús, UNSAM-CONICET, (1650) San Martín, Provincia de Buenos Aires, Argentina.)
Abstract	RNA-binding proteins (RBPs) and RNA metabolism are considered to be important for modulating gene expression in trypanosomes, because these protozoan parasites mainly rely on post-transcriptional mechanisms to regulate protein levels. Previously, we have identified TcUBP1, a single RNA recognition motif (RRM)-type RBP from Trypanosoma cruzi. TcUBP1 is a cytoplasmic protein with roles in stabilization/degradation of mRNAs and in the protection of transcripts through their recruitment into cytoplasmic granules. We now show that TcUBP1, and the closely related protein TcUBP2, can be found in small amounts in the nucleus under normal conditions, and are able to accumulate in the nucleus under arsenite stress. The kinetics of nuclear accumulation, and export to the cytoplasm, are consistent with the shuttling of TcUBP1 between the nucleus and the cytoplasm. The sequence required for TcUBP1 nuclear accumulation was narrowed to the RRM, and point mutations affecting RNA binding abolished nuclear import. This RRM was also shown to be efficiently exported from the nucleus in unstressed parasites, a property that relied on the binding to RNA. TcUBP1 nuclear accumulation was dependent on active transcription, and colocalized with transcripts in the nucleus, suggesting nuclear binding of the mRNA. We propose that TcUBP1 could be linking the mRNA metabolism at both sides of the nuclear pore complex, using the RRM as a nuclear localization signal, and being exported as a cargo on mRNA.
ISSN	00219258
e-ISSN	1083351X
Journal	Journal of Biological Chemistry
Issue Number	50
Volume Number	284
Language	English
Publisher	American Society for Biochemistry and Molecular Biology (United States)
Publisher Date	2009-12-11
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Active Transport, Cell Nucleus Physiology RNA-Binding Proteins Metabolism Trypanosoma Cruzi Amino Acid Sequence Animals Arsenites Cell Nucleus Models, Molecular Molecular Sequence Data Nuclear Localization Signals Nuclear Pore Oxidative Stress Protein Conformation Protozoan Proteins Genetics RNA, Messenger Recombinant Fusion Proteins Transcription, Genetic Cytology Research Support, Non-U.S. Gov't Biochemistry Molecular Biology
Content Type	Text
Resource Type	Article
Subject	Cell Biology Biochemistry Molecular Biology

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