NDLI: A tRNA-independent mechanism for transamidosome assembly promotes aminoacyl-tRNA transamidation.

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A tRNA-independent mechanism for transamidosome assembly promotes aminoacyl-tRNA transamidation.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Floyd, Ashley M. Fatma, Shirin Cruz, Amanda N. Joshi, Nilesh Hendrickson, Tamara L. Kern, Daniel Chuawong, Pitak Silva, Gayathri N. Fischer, Frederic Simari, Rachel M.
Description	Author Affiliation: Silva GN ( Department of Chemistry, Wayne State University, Detroit, Michigan 48230, USA.)
Abstract	Many bacteria lack genes encoding asparaginyl- and/or glutaminyl-tRNA synthetase and consequently rely on an indirect path for the synthesis of both Asn-tRNA(Asn) and Gln-tRNA(Gln). In some bacteria such as Thermus thermophilus, efficient delivery of misacylated tRNA to the downstream amidotransferase (AdT) is ensured by formation of a stable, tRNA-dependent macromolecular complex called the Asn-transamidosome. This complex enables direct delivery of Asp-tRNA(Asn) from the non-discriminating aspartyl-tRNA synthetase to AdT, where it is converted into Asn-tRNA(Asn). Previous characterization of the analogous Helicobacter pylori Asn-transamidosome revealed that it is dynamic and cannot be stably isolated, suggesting the possibility of an alternative mechanism to facilitate assembly of a stable complex. We have identified a novel protein partner called Hp0100 as a component of a stable, tRNA-independent H. pylori Asn-transamidosome; this complex contains a non-discriminating aspartyl-tRNA synthetase, AdT, and Hp0100 but does not require tRNA(Asn) for assembly. Hp0100 also enhances the capacity of AdT to convert Asp-tRNA(Asn) into Asn-tRNA(Asn) by â ¼35-fold. Our results demonstrate that bacteria have adopted multiple divergent methods for transamidosome assembly and function.
ISSN	00219258
e-ISSN	1083351X
Journal	Journal of Biological Chemistry
Issue Number	6
Volume Number	288
Language	English
Publisher	American Society for Biochemistry and Molecular Biology (United States)
Publisher Date	2013-02-08
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Amidinotransferases Metabolism Bacterial Proteins Helicobacter Pylori Enzymology Multienzyme Complexes RNA, Bacterial RNA, Transfer, Amino Acyl Genetics Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Biochemistry Molecular Biology
Content Type	Text
Resource Type	Article
Subject	Cell Biology Biochemistry Molecular Biology

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